Gut microbial dysbiosis in the pathogenesis of leukemia: an immune-based perspective.

Autor: Goswami M; Department of Molecular Biology and Biotechnology, Cotton University, Panbazar, Guwahati, Assam, India., Bose PD; Department of Molecular Biology and Biotechnology, Cotton University, Panbazar, Guwahati, Assam, India. Electronic address: pdbose@cottonuniversity.ac.in.
Jazyk: angličtina
Zdroj: Experimental hematology [Exp Hematol] 2024 May; Vol. 133, pp. 104211. Date of Electronic Publication: 2024 Mar 26.
DOI: 10.1016/j.exphem.2024.104211
Abstrakt: Leukemias are a set of clonal hematopoietic malignant diseases that develop in the bone marrow. Several factors influence leukemia development and progression. Among these, the gut microbiota is a major factor influencing a wide array of its processes. The gut microbial composition is linked to the risk of tumor development and the host's ability to respond to treatment, mostly due to the immune-modulatory effects of their metabolites. Despite such strong evidence, its role in the development of hematologic malignancies still requires attention of investigators worldwide. In this review, we make an effort to discuss the role of host gut microbiota-immune crosstalk in leukemia development and progression. Additionally, we highlight certain recently developed strategies to modify the gut microbial composition that may help to overcome dysbiosis in leukemia patients in the near future.
Competing Interests: Conflicts of Interest Disclosure The authors declare no competing financial interests.
(Copyright © 2024 ISEH -- Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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