N-of-1 medicine.

Autor: Wang P; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore.; Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore., Leong QY; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore., Lau NY; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore., Ng WY; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore., Kwek SP; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore., Tan L; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore.; Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore., Song SW; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore.; Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore., You K; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore.; Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore., Chong LM; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore.; Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore., Zhuang I; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore., Ong YH; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore., Foo N; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore.; Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore., Tadeo X; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore., Kumar KS; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore., Vijayakumar S; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore., Sapanel Y; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore.; Singapore's Health District @ Queenstown, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Raczkowska MN; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore., Remus A; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore.; Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore.; Heat Resilience Performance Centre (HRPC), Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Blasiak A; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore.; Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Ho D; Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; The N.1 Institute for Health (N.1), National University of Singapore, Singapore.; Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore.; Singapore's Health District @ Queenstown, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; The Bia-Echo Asia Centre for Reproductive Longevity and Equality, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Jazyk: angličtina
Zdroj: Singapore medical journal [Singapore Med J] 2024 Mar 01; Vol. 65 (3), pp. 167-175. Date of Electronic Publication: 2024 Mar 26.
DOI: 10.4103/singaporemedj.SMJ-2023-243
Abstrakt: Abstract: The fields of precision and personalised medicine have led to promising advances in tailoring treatment to individual patients. Examples include genome/molecular alteration-guided drug selection, single-patient gene therapy design and synergy-based drug combination development, and these approaches can yield substantially diverse recommendations. Therefore, it is important to define each domain and delineate their commonalities and differences in an effort to develop novel clinical trial designs, streamline workflow development, rethink regulatory considerations, create value in healthcare and economics assessments, and other factors. These and other segments are essential to recognise the diversity within these domains to accelerate their respective workflows towards practice-changing healthcare. To emphasise these points, this article elaborates on the concept of digital health and digital medicine-enabled N-of-1 medicine, which individualises combination regimen and dosing using a patient's own data. We will conclude with recommendations for consideration when developing novel workflows based on emerging digital-based platforms.
(Copyright © 2024 Copyright: © 2024 Singapore Medical Journal.)
Databáze: MEDLINE
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