Probing the Dynamic Landscape: From Static to Time-Resolved X-Ray Absorption Spectroscopy to Investigate Copper Redox Chemistry in Neurodegenerative Disorders.

Autor: De Santis E; Department of Chemistry-BMC, Uppsala University, Box 576, SE-751 23, Uppsala, Sweden., Alleva S; Department of Physics, University of Rome, Tor Vergata, Rome, 00133, Italy.; INFN, Rome, Tor Vergata, Rome, 00133, Italy., Minicozzi V; Department of Physics, University of Rome, Tor Vergata, Rome, 00133, Italy.; INFN, Rome, Tor Vergata, Rome, 00133, Italy., Morante S; Department of Physics, University of Rome, Tor Vergata, Rome, 00133, Italy.; INFN, Rome, Tor Vergata, Rome, 00133, Italy., Stellato F; Department of Physics, University of Rome, Tor Vergata, Rome, 00133, Italy.; INFN, Rome, Tor Vergata, Rome, 00133, Italy.
Jazyk: angličtina
Zdroj: ChemPlusChem [Chempluschem] 2024 Jul; Vol. 89 (7), pp. e202300712. Date of Electronic Publication: 2024 Apr 29.
DOI: 10.1002/cplu.202300712
Abstrakt: Copper (Cu), with its ability to exist in various oxidation states, notably Cu(I) and Cu(II), plays a crucial role in diverse biological redox reactions. This includes its involvement in pathways associated with oxidative stress in neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Transmissible Spongiform Encephalopathies. This paper offers an overview of X-ray Absorption Spectroscopy (XAS) studies designed to elucidate the interactions between Cu ions and proteins or peptides associated with these neurodegenerative diseases. The emphasis lies on XAS specificity, revealing the local coordination environment, and on its sensitivity to Cu oxidation states. Furthermore, the paper focuses on XAS applications targeting the characterization of intermediate reaction states and explores the opportunities arising from recent advancements in time-resolved XAS at ultrabright synchrotron and Free Electron Laser radiation sources.
(© 2024 Wiley-VCH GmbH.)
Databáze: MEDLINE
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