Barriers toward xenotransplantation in Arab World.

Autor: Ghazi M; Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.; Faculty of Medical Sciences, Lebanese University, Beirut, Lebanon., Saleh A; Faculty of Medical Sciences, Lebanese University, Beirut, Lebanon., Abdallah M; Faculty of Medical Sciences, Lebanese University, Beirut, Lebanon., El Masri D; Faculty of Medical Sciences, Lebanese University, Beirut, Lebanon.; Faculty of Medicine, University of Balamand, Koura, Lebanon., El Masri J; Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.; Faculty of Medical Sciences, Lebanese University, Beirut, Lebanon., El Ayoubi LM; Faculty of Medical Sciences, Lebanese University, Beirut, Lebanon., Hawi J; Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon., Jurjus A; Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Jazyk: angličtina
Zdroj: Xenotransplantation [Xenotransplantation] 2024 Mar-Apr; Vol. 31 (2), pp. e12852.
DOI: 10.1111/xen.12852
Abstrakt: Organ transplant is a crucial therapeutic strategy offering a life-saving and transformative medical intervention. It provides an opportunity to improve their quality of life and increase their lifespan. The shortage of organs remains a critical global challenge, leading to a prolonged waiting times for organ receivers, which contributes to an increase in morbidity and mortality rates. Hence, xenotransplantation offered a promising solution to the global shortage of organs through the use of animal organs, leading to an increase in donor availability, reducing waiting times, minimizing organ trafficking, improving genetic engineering advancements, and driving scientific innovation. Even though xenotransplantation has many benefits in the clinical setting, it has many barriers that are hindering its achievements and constraining its occurrence. Some barriers to xenotransplant are general, such as the immunological barrier, while others are specific to certain regions due to local causes. The Arab region exhibits disparities in clinical settings compared to the global context, marked by the huge economic crisis and a shortage of trained healthcare professionals. Considering the huge resources and advancements needed in the field of xenotransplantation, this review aims to explore the specific barriers toward xenotransplantation in the Arab countries, highlighting the challenges to overcome these barriers.
(© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
Externí odkaz: