| Autor: |
Piergentili R; Institute of Molecular Biology and Pathology, Italian National Research Council (CNR-IBPM), 00185 Rome, Italy., Marinelli E; Department of Medico-Surgical Sciences and Biotechnologies, 'Sapienza' University of Rome, 04100 Latina, Italy., Cucinella G; Department of Obstetrics and Gynecology, Villa Sofia Cervello Hospital, University of Palermo, 90146 Palermo, Italy., Lopez A; Department of Obstetrics and Gynecology, Villa Sofia Cervello Hospital, University of Palermo, 90146 Palermo, Italy., Napoletano G; Department of Anatomical, Histological, Forensic and Orthopedic Sciences, Section of Forensic Medicine, 'Sapienza' University of Rome, 00161 Rome, Italy., Gullo G; Department of Obstetrics and Gynecology, Villa Sofia Cervello Hospital, University of Palermo, 90146 Palermo, Italy., Zaami S; Department of Anatomical, Histological, Forensic and Orthopedic Sciences, Section of Forensic Medicine, 'Sapienza' University of Rome, 00161 Rome, Italy. |
| Abstrakt: |
Breast Cancer (BC) is one of the most common cancer types worldwide, and it is characterized by a complex etiopathogenesis, resulting in an equally complex classification of subtypes. MicroRNA (miRNA or miR) are small non-coding RNA molecules that have an essential role in gene expression and are significantly linked to tumor development and angiogenesis in different types of cancer. Recently, complex interactions among coding and non-coding RNA have been elucidated, further shedding light on the complexity of the roles these molecules fulfill in cancer formation. In this context, knowledge about the role of miR in BC has significantly improved, highlighting the deregulation of these molecules as additional factors influencing BC occurrence, development and classification. A considerable number of papers has been published over the past few years regarding the role of miR-125 in human pathology in general and in several types of cancer formation in particular. Interestingly, miR-125 family members have been recently linked to BC formation as well, and complex interactions (competing endogenous RNA networks, or ceRNET) between this molecule and target mRNA have been described. In this review, we summarize the state-of-the-art about research on this topic. |
