| Autor: |
Viglione MS; Department of Electrical and Computer Engineering, Brigham Young University, Provo, USA. nordin@byu.edu., Saxton A; Department of Chemistry and Biochemistry, Brigham Young University, Provo, USA., Downs D; Department of Chemistry and Biochemistry, Brigham Young University, Provo, USA., Woolley AT; Department of Chemistry and Biochemistry, Brigham Young University, Provo, USA., Christensen KA; Department of Chemistry and Biochemistry, Brigham Young University, Provo, USA., Van Ry PM; Department of Chemistry and Biochemistry, Brigham Young University, Provo, USA., Nordin GP; Department of Electrical and Computer Engineering, Brigham Young University, Provo, USA. nordin@byu.edu. |
| Abstrakt: |
In this work, we present a new 3D printing technique that enables the realization of native digital micro-mirror device (DMD) resolution in negative features of a 3D printed part without improving 3D printer hardware and demonstrate the fabrication of fully integrated, biocompatible isoporous membranes with pore sizes as small as 7 μm. We utilize this technique to construct a microfluidic device that mimics an established organ-on-a-chip configuration, including an integrated isoporous membrane. Two cell populations are seeded on either side of the membrane and imaged as a proof of concept for other organ-on-a-chip applications. These 3D printed isoporous membranes can be leveraged for a wide variety of other mechanical and biological applications, creating new possibilities for seamlessly integrated, 3D printed microfluidic devices. |
