Bacterial diversity and chemical ecology of natural product-producing bacteria from Great Salt Lake sediment.

Autor:	Bring Horvath ER; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, United States.; School of Biological Sciences, University of Utah, Salt Lake City, UT 84112, United States.; Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112, United States., Brazelton WJ; School of Biological Sciences, University of Utah, Salt Lake City, UT 84112, United States., Kim MC; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, CA 92093, United States., Cullum R; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, CA 92093, United States., Mulvey MA; School of Biological Sciences, University of Utah, Salt Lake City, UT 84112, United States.; Henry Eyring Center for Cell and Genome Science, University of Utah, Salt Lake City, UT 84112, United States., Fenical W; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, CA 92093, United States.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, CA 92093, United States.; Moores Comprehensive Cancer Center, University of California at San Diego, CA 92037, United States., Winter JM; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, United States.
Jazyk:	angličtina
Zdroj:	ISME communications [ISME Commun] 2024 Mar 04; Vol. 4 (1), pp. ycae029. Date of Electronic Publication: 2024 Mar 04 (Print Publication: 2024).
DOI:	10.1093/ismeco/ycae029
Abstrakt:	Great Salt Lake (GSL), located northwest of Salt Lake City, UT, is the largest terminal lake in the USA. While the average salinity of seawater is ~3.3%, the salinity in GSL ranges between 5% and 28%. In addition to being a hypersaline environment, GSL also contains toxic concentrations of heavy metals, such as arsenic, mercury, and lead. The extreme environment of GSL makes it an intriguing subject of study, both for its unique microbiome and its potential to harbor novel natural product-producing bacteria, which could be used as resources for the discovery of biologically active compounds. Though work has been done to survey and catalog bacteria found in GSL, the Lake's microbiome is largely unexplored, and little to no work has been done to characterize the natural product potential of GSL microbes. Here, we investigate the bacterial diversity of two important regions within GSL, describe the first genomic characterization of Actinomycetota isolated from GSL sediment, including the identification of two new Actinomycetota species, and provide the first survey of the natural product potential of GSL bacteria. Competing Interests: None declared. (© The Author(s) 2024. Published by Oxford University Press on behalf of the International Society for Microbial Ecology.)
Databáze:	MEDLINE
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