| Autor: |
Yount TA; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA., Murtha AN; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA., Cecere AG; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA., Miyashiro TI; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA. |
| Jazyk: |
angličtina |
| Zdroj: |
Israel journal of chemistry [Isr J Chem] 2023 Jun; Vol. 63 (5-6). Date of Electronic Publication: 2022 Nov 02. |
| DOI: |
10.1002/ijch.202200061 |
| Abstrakt: |
Quorum sensing is an intercellular signaling mechanism that enables bacterial cells to coordinate population-level behaviors. How quorum sensing functions in natural habitats remains poorly understood. Vibrio fischeri is a bacterial symbiont of the Hawaiian bobtail squid Euprymna scolopes and depends on LuxI/LuxR quorum sensing to produce the symbiotic trait of bioluminescence. A previous study demonstrated that animals emit light when co-colonized by a Δ lux mutant, which lacks several genes within the lux operon that are necessary for bioluminescence production, and a LuxI - mutant, which cannot synthesize the quorum signaling molecule N -3-oxohexanoyl-homoserine lactone. Here, we build upon that observation and show that populations of LuxI - feature elevated promoter activity for the lux operon. We find that population structures comprising of Δ lux and LuxI - are attenuated within the squid, but a wild-type strain enables the LuxI - strain type to be maintained in vivo . These experimental results support a model of interpopulation signaling, which provides basic insight into how quorum sensing functions within the natural habitats found within a host. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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