Novel Deliberately Sensitive and Selective Tetrahydrozoline Voltammetric Sensors Integrated with a Copper Oxide Nanoparticle/Zeolite Platform.

Autor:	Abumelha HM; Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia., Sayqal A; Department of Chemistry, College of Sciences, Umm Al-Qura University, Makkah 24230, Saudi Arabia., Snari RM; Department of Chemistry, College of Sciences, Umm Al-Qura University, Makkah 24230, Saudi Arabia., Alkhamis KM; Department of Chemistry, Faculty of Science, University of Tabouk, Tabouk 71421, Saudi Arabia., Alharbi A; Department of Chemistry, College of Sciences, Umm Al-Qura University, Makkah 24230, Saudi Arabia., Al-Ahmed ZA; Applied College Dhahran Aljanoub, King Khalid University, Abha 61421, Saudi Arabia., El-Metwaly NM; Department of Chemistry, College of Sciences, Umm Al-Qura University, Makkah 24230, Saudi Arabia.; Department of Chemistry, Faculty of Science, Mansoura University, Mansoura 002050, Egypt.
Jazyk:	angličtina
Zdroj:	ACS omega [ACS Omega] 2024 Mar 08; Vol. 9 (11), pp. 13458-13468. Date of Electronic Publication: 2024 Mar 08 (Print Publication: 2024).
DOI:	10.1021/acsomega.4c00370
Abstrakt:	The present study introduced a novel disposable screen-printed carbon electrodes (SPCEs) modified with copper oxide/zeolite nanostructures for eco-friendly selective differential pulse voltammetric quantification of tetrahydrozoline (THZ) in eyedrop samples and biological fluids. Modification of the electrode matrix with copper oxide nanoparticles/zeolite nanostructures (CuONPs/ZY) with their effective and synergistic electrocatalytic activity enhanced the electrode performance against electrooxidation of THZ at 0.960 V in BR at pH 9.0 with a diffusion-controlled reaction mechanism. The tentative oxidation mechanism based on molecular orbital calculations postulates the oxidation of THZ molecules through oxidation of a nitrogen atom five-membered ring and the participation of two electrons/protons in the electrode reaction. Linear calibration curves were illustrated within a wide THZ concentration range from 0.24 to 57.2 μg mL -1 recording a limit of detection (LOD) value of 0.0799 μg mL -1 . The CuONPs/ZY/SPEs exhibited improved performance compared with the sole reported THZ sensor-based gold film-plated carbon paste electrodes, in addition to their high reproducibility of fabrication and measurement and prolonged shelf lifetime. Tetrahydrozoline was successfully assayed in the presence of excipients, degradation products, and chloramphenicol. The presented voltammetric sensor can be considered as an eco-friendly and reliable analytical approach for monitoring THZ residues in eye drop samples and biological fluids with high recovery compared with the official pharmacopeial analytical protocol. The presented sensors were assessed according to an EcoScale tool and also compared with the reported THZ sensor. Competing Interests: The authors declare no competing financial interest. (© 2024 The Authors. Published by American Chemical Society.)
Databáze:	MEDLINE
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