Physical exercise frequency and cognition: a multicenter cross-sectional cohort study.

Autor:	Wen C; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing, China., Gan JH; Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China., Huang GW; Department of Nutrition and Food Science, Tianjin Key Laboratory of Environment, Nutrition and Public Health, School of Public Health, Tianjin Medical University, Tianjin, China., Wang XD; Department of Neurology, Tianjin Huanhu Hospital, Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin Dementia Institute, Tianjin, China., Lü Y; Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Niu JP; Department of Neurology, The Second Affiliated Hospital of Xiamen Medical College, Xiamen, China., Meng XL; Department of Neurology, Affiliated Traditional Chinese Medicine Hospital of Xinjiang Medical University, Urumqi, China., Cai P; Dementia Clinic, Affiliated Hospital of Zunyi Medical University, Zunyi, China., Li Y; Department of Neurology, The First Hospital of Shanxi Medical University, Taiyuan, China., Gang BZ; Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, China., You Y; Department of Neurology, Second Affiliated Hospital of Hainan Medical University, Haikou, China., Lv Y; Department of Neurology, Hainan General Hospital, Haikou, China., Ren ZH; Department of Neurology, Beijing Electric Power Hospital, State Grid Corporation of China, Capital Medical University, Beijing, China., Liu S; Department of Neurology, Tianjin Huanhu Hospital, Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin Dementia Institute, Tianjin, China., Zeng Y; Brain Science and Advanced Technology Institute, Wuhan University of Science and Technology, Wuhan, China., Ji Y; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing, China.; Department of Neurology, Tianjin Huanhu Hospital, Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin Dementia Institute, Tianjin, China.
Jazyk:	angličtina
Zdroj:	Frontiers in aging neuroscience [Front Aging Neurosci] 2024 Mar 08; Vol. 16, pp. 1381692. Date of Electronic Publication: 2024 Mar 08 (Print Publication: 2024).
DOI:	10.3389/fnagi.2024.1381692
Abstrakt:	Background and Aims: Dementia imposes a heavy burden on society and families, therefore, effective drug treatments, exploring and preventing factors associated with dementia, are paramount. To provide reference points for the best frequency of physical exercise (physical exercise), we investigated the association between frequency of PE and cognition in Chinese old adults. Methods: 16,181 Chinese participants aged 65 years or older were included in this study. Associations between PE and cognition were estimated multivariate logistic and linear regression analyses. Associations were further investigated across dementia subtypes (Alzheimer dementia, vascular dementia, and other types of dementia). Subgroup analyses were performed in different age groups, in populations with and without stroke, and those with and without hypertension. Results: PE associated with dementia after adjusting for full covariates (OR: 0.5414, 95% CI: 0.4536-0.6491, p  < 0.001). Exercise performed at ≥3 times/week associated with lower risk of dementia (OR: 0.4794-0.6619, all p value <0.001). PE was associated with improved cognition ( β : 12851, p  < 0.001), and any PE frequency contributed to cognitive improvement ( p values for exercise performed ≥1 time/week were <0.001). Similar conclusions were identified when we repeated analyses in different dementia subtypes and age groups. Subgroup analyses suggested that the cognition of individuals without hypertension also benefitted from exercising 1-2 times/week (OR: 0.6168, 95% CI: 0.4379-0.8668, p  = 0.005). Conclusion: The best exercise frequency is exercising ≥3 times/week for individuals from different dementia subtypes and age groups. While for those without hypertension, PE at 1-2 times /week is also beneficial. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Wen, Gan, Huang, Wang, Lü, Niu, Meng, Cai, Li, Gang, You, Lv, Ren, Liu, Zeng and Ji.)
Databáze:	MEDLINE
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