Regional covariance of white matter hyperintensity volume patterns associated with hippocampal volume in healthy aging.

Autor:	Van Etten EJ; Department of Psychology, University of Arizona, Tucson, AZ, United States.; Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, United States., Bharadwaj PK; Department of Psychology, University of Arizona, Tucson, AZ, United States.; Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, United States., Grilli MD; Department of Psychology, University of Arizona, Tucson, AZ, United States.; Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, United States.; Department of Neurology, University of Arizona, Tucson, AZ, United States., Raichlen DA; Human and Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, United States.; Department of Anthropology, University of Southern California, Los Angeles, CA, United States., Hishaw GA; Department of Neurology, University of Arizona, Tucson, AZ, United States., Huentelman MJ; Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, United States.; Neurogenomics Division, The Translational Genomics Research Institute (TGen), Phoenix, AZ, United States.; Arizona Alzheimer's Consortium, Phoenix, AZ, United States., Trouard TP; Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, United States.; Arizona Alzheimer's Consortium, Phoenix, AZ, United States.; Department of Biomedical Engineering, University of Arizona, Tucson, AZ, United States., Alexander GE; Department of Psychology, University of Arizona, Tucson, AZ, United States.; Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, United States.; Arizona Alzheimer's Consortium, Phoenix, AZ, United States.; Department of Psychiatry, University of Arizona, Tucson, AZ, United States.; Neuroscience Graduate Interdisciplinary Program, University of Arizona, Tucson, AZ, United States.; Physiological Sciences Graduate Interdisciplinary Program, University of Arizona, Tucson, AZ, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in aging neuroscience [Front Aging Neurosci] 2024 Mar 08; Vol. 16, pp. 1349449. Date of Electronic Publication: 2024 Mar 08 (Print Publication: 2024).
DOI:	10.3389/fnagi.2024.1349449
Abstrakt:	Hippocampal volume is particularly sensitive to the accumulation of total brain white matter hyperintensity volume (WMH) in aging, but how the regional distribution of WMH volume differentially impacts the hippocampus has been less studied. In a cohort of 194 healthy older adults ages 50-89, we used a multivariate statistical method, the Scaled Subprofile Model (SSM), to (1) identify patterns of regional WMH differences related to left and right hippocampal volumes, (2) examine associations between the multimodal neuroimaging covariance patterns and demographic characteristics, and (3) investigate the relation of the patterns to subjective and objective memory in healthy aging. We established network covariance patterns of regional WMH volume differences associated with greater left and right hippocampal volumes, which were characterized by reductions in left temporal and right parietal WMH volumes and relative increases in bilateral occipital WMH volumes. Additionally, we observed lower expression of these hippocampal-related regional WMH patterns were significantly associated with increasing age and greater subjective memory complaints, but not objective memory performance in this healthy older adult cohort. Our findings indicate that, in cognitively healthy older adults, left and right hippocampal volume reductions were associated with differences in the regional distribution of WMH volumes, which were exacerbated by advancing age and related to greater subjective memory complaints. Multivariate network analyses, like SSM, may help elucidate important early effects of regional WMH volume on brain and cognitive aging in healthy older adults. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Van Etten, Bharadwaj, Grilli, Raichlen, Hishaw, Huentelman, Trouard and Alexander.)
Databáze:	MEDLINE
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