Sex Differences in Response Inhibition-Related Neural Predictors of Posttraumatic Stress Disorder in Civilians With Recent Trauma.

Autor: Borst B; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia; Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Jovanovic T; Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan., House SL; Department of Emergency Medicine, Washington University School of Medicine, St. Louis, Missouri., Bruce SE; Department of Psychological Sciences, University of Missouri St. Louis, St. Louis, Missouri., Harnett NG; Division of Depression and Anxiety, McLean Hospital, Belmont, Massachusetts; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts., Roeckner AR; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia., Ely TD; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia., Lebois LAM; Division of Depression and Anxiety, McLean Hospital, Belmont, Massachusetts; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts., Young D; Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, California., Beaudoin FL; Department of Epidemiology, Brown University, Rehabilitation International, Providence, Rhode Island; Department of Emergency Medicine, Brown University, Providence, Rhode Island., An X; Institute for Trauma Recovery, Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Neylan TC; Departments of Psychiatry and Neurology, University of California San Francisco, San Francisco, California., Clifford GD; Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, Georgia; Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia., Linnstaedt SD; Institute for Trauma Recovery, Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Germine LT; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts; Institute for Technology in Psychiatry, McLean Hospital, Belmont, Massachusetts; Many Brains Project, Belmont, Massachusetts., Bollen KA; Department of Psychology and Neuroscience & Department of Sociology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Rauch SL; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts; Institute for Technology in Psychiatry, McLean Hospital, Belmont, Massachusetts; Department of Psychiatry, McLean Hospital, Belmont, Massachusetts., Haran JP; Department of Emergency Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts., Storrow AB; Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Lewandowski C; Department of Emergency Medicine, Henry Ford Health System, Detroit, Michigan., Musey PI Jr; Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, Indiana., Hendry PL; Department of Emergency Medicine, University of Florida College of Medicine, Jacksonville, Jacksonville, Florida., Sheikh S; Department of Emergency Medicine, University of Florida College of Medicine, Jacksonville, Jacksonville, Florida., Jones CW; Department of Emergency Medicine, Cooper Medical School of Rowan University, Camden, New Jersey., Punches BE; Department of Emergency Medicine, Ohio State University College of Medicine, Columbus, Ohio; Ohio State University College of Nursing, Columbus, Ohio., Hudak LA; Department of Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia., Pascual JL; Department of Surgery, Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Seamon MJ; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Surgery, Division of Traumatology, Surgical Critical Care and Emergency Surgery, University of Pennsylvania, Philadelphia, Pennsylvania., Datner EM; Department of Emergency Medicine, Jefferson Einstein Hospital, Jefferson Health, Philadelphia, Pennsylvania; Department of Emergency Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania., Pearson C; Department of Emergency Medicine, Wayne State University, Ascension St. John Hospital, Detroit, Michigan., Peak DA; Department of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts., Domeier RM; Department of Emergency Medicine, Trinity Health, Ann Arbor, Ypsilanti, Michigan., Rathlev NK; Department of Emergency Medicine, University of Massachusetts Medical School-Baystate, Springfield, Massachusetts., O'Neil BJ; Department of Emergency Medicine, Wayne State University, Detroit Receiving Hospital, Detroit, Michigan., Sergot P; Department of Emergency Medicine, McGovern Medical School at UTHealth, Houston, Texas., Sanchez LD; Department of Emergency Medicine, Brigham and Women's Hospital, Boston, Massachusetts; Department of Emergency Medicine, Harvard Medical School, Boston, Massachusetts., Harte SE; Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan; Department of Internal Medicine-Rheumatology, University of Michigan Medical School, Ann Arbor, Michigan., Koenen KC; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts., Kessler RC; Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts., McLean SA; Department of Emergency Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Institute for Trauma Recovery, Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Ressler KJ; Division of Depression and Anxiety, McLean Hospital, Belmont, Massachusetts; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts., Stevens JS; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia., van Rooij SJH; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia. Electronic address: sanne.van.rooij@emory.edu.
Jazyk: angličtina
Zdroj: Biological psychiatry. Cognitive neuroscience and neuroimaging [Biol Psychiatry Cogn Neurosci Neuroimaging] 2024 Jul; Vol. 9 (7), pp. 668-680. Date of Electronic Publication: 2024 Mar 22.
DOI: 10.1016/j.bpsc.2024.03.002
Abstrakt: Background: Females are more likely to develop posttraumatic stress disorder (PTSD) than males. Impaired inhibition has been identified as a mechanism for PTSD development, but studies on potential sex differences in this neurobiological mechanism and how it relates to PTSD severity and progression are relatively rare. Here, we examined sex differences in neural activation during response inhibition and PTSD following recent trauma.
Methods: Participants (n = 205, 138 female sex assigned at birth) were recruited from emergency departments within 72 hours of a traumatic event. PTSD symptoms were assessed 2 weeks and 6 months posttrauma. A Go/NoGo task was performed 2 weeks posttrauma in a 3T magnetic resonance imaging scanner to measure neural activity during response inhibition in the ventromedial prefrontal cortex, right inferior frontal gyrus, and bilateral hippocampus. General linear models were used to examine the interaction effect of sex on the relationship between our regions of interest and the whole brain, PTSD symptoms at 6 months, and symptom progression between 2 weeks and 6 months.
Results: Lower response inhibition-related ventromedial prefrontal cortex activation 2 weeks posttrauma predicted more PTSD symptoms at 6 months in females but not in males, while greater response inhibition-related right inferior frontal gyrus activation predicted lower PTSD symptom progression in males but not females. Whole-brain interaction effects were observed in the medial temporal gyrus and left precentral gyrus.
Conclusions: There are sex differences in the relationship between inhibition-related brain activation and PTSD symptom severity and progression. These findings suggest that sex differences should be assessed in future PTSD studies and reveal potential targets for sex-specific interventions.
(Copyright © 2024 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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