Developments and future prospects of personalized medicine in head and neck squamous cell carcinoma diagnoses and treatments.

Autor: Jayawickrama SM; Centre for Research in Oral Cancer, Faculty of Dental Sciences, University of Peradeniya, Kandy, Sri Lanka., Ranaweera PM; Faculty of Information Technology, Horizon Campus, Colombo, Sri Lanka., Pradeep RGGR; Centre for Research in Oral Cancer, Faculty of Dental Sciences, University of Peradeniya, Kandy, Sri Lanka., Jayasinghe YA; Centre for Research in Oral Cancer, Faculty of Dental Sciences, University of Peradeniya, Kandy, Sri Lanka., Senevirathna K; Centre for Research in Oral Cancer, Faculty of Dental Sciences, University of Peradeniya, Kandy, Sri Lanka., Hilmi AJ; Oncology and Radiotherapy Unit, National Hospital, Kandy, Sri Lanka., Rajapakse RMG; Department of Chemistry, Faculty of Sciences, University of Peradeniya, Kandy, Sri Lanka., Kanmodi KK; School of Dentistry, University of Rwanda, Kigali, Rwanda.; Faculty of Dentistry, University of Puthisastra, Phnom Penh, Cambodia.; Cephas Health Research Initiative Inc, Ibadan, Nigeria.; School of Health and Life Sciences, Teesside University, Middlesbrough, UK., Jayasinghe RD; Centre for Research in Oral Cancer, Faculty of Dental Sciences, University of Peradeniya, Kandy, Sri Lanka.; Faculty of Dentistry, University of Puthisastra, Phnom Penh, Cambodia.; School of Health and Life Sciences, Teesside University, Middlesbrough, UK.; Department of Oral Medicine and Periodontology, Faculty of Dental Sciences, University of Peradeniya, Kandy, Sri Lanka.
Jazyk: angličtina
Zdroj: Cancer reports (Hoboken, N.J.) [Cancer Rep (Hoboken)] 2024 Mar; Vol. 7 (3), pp. e2045.
DOI: 10.1002/cnr2.2045
Abstrakt: Background: Precision healthcare has entered a new era because of the developments in personalized medicine, especially in the diagnosis and treatment of head and neck squamous cell carcinoma (HNSCC). This paper explores the dynamic landscape of personalized medicine as applied to HNSCC, encompassing both current developments and future prospects.
Recent Findings: The integration of personalized medicine strategies into HNSCC diagnosis is driven by the utilization of genetic data and biomarkers. Epigenetic biomarkers, which reflect modifications to DNA that can influence gene expression, have emerged as valuable indicators for early detection and risk assessment. Treatment approaches within the personalized medicine framework are equally promising. Immunotherapy, gene silencing, and editing techniques, including RNA interference and CRISPR/Cas9, offer innovative means to modulate gene expression and correct genetic aberrations driving HNSCC. The integration of stem cell research with personalized medicine presents opportunities for tailored regenerative approaches. The synergy between personalized medicine and technological advancements is exemplified by artificial intelligence (AI) and machine learning (ML) applications. These tools empower clinicians to analyze vast datasets, predict patient responses, and optimize treatment strategies with unprecedented accuracy.
Conclusion: The developments and prospects of personalized medicine in HNSCC diagnosis and treatment offer a transformative approach to managing this complex malignancy. By harnessing genetic insights, biomarkers, immunotherapy, gene editing, stem cell therapies, and advanced technologies like AI and ML, personalized medicine holds the key to enhancing patient outcomes and ushering in a new era of precision oncology.
(© 2024 The Authors. Cancer Reports published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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