The successful treatment of mpox with brincidofovir in renal transplant recipients-a report of 2 cases.

Autor:	Alameer RM; Section of Transplant Infectious Diseases, Organ Transplant Center of Excellence, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. Electronic address: reem89alameer@gmail.com., Yamani A; Section of Transplant Infectious Diseases, Organ Transplant Center of Excellence, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia., Al-Saud A; Section of Transplant Infectious Diseases, Organ Transplant Center of Excellence, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia., Alsobayeg S; Department of Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia., Alamro B; Department of Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia., Alali A; Department of Infectious Diseases, King Saud Medical City, Riyadh, Saudi Arabia., Hammad E; Kidney and Pancreas Health Center, Organ Transplant Center of Excellence, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia., Shendi AM; Kidney and Pancreas Health Center, Organ Transplant Center of Excellence, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia., Almaghrabi RS; Section of Transplant Infectious Diseases, Organ Transplant Center of Excellence, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Jazyk:	angličtina
Zdroj:	International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2024 Jun; Vol. 143, pp. 107015. Date of Electronic Publication: 2024 Mar 21.
DOI:	10.1016/j.ijid.2024.107015
Abstrakt:	An mpox outbreak was declared in July 2022 by the world health organization (WHO). It causes a mild self-limiting disease however; in immunosuppressed hosts, it tends to cause severe disseminated infection. Most cases of mpox in sold organ transplant (SOT) recipients reported in the literature were treated with tecovirimat. Here we report two cases of severe disseminated mpox infection in renal transplant recipients that were successfully treated with brincidofovir. Both patients were discharged from the hospital with no immediate significant side effects from brincidofovir reported until the submission of this report. (Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze:	MEDLINE
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