Advancing in vivo reprogramming with synthetic biology.

Autor: Islam F; Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA., Lewis MR; Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA., Craig JD; Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA., Leyendecker PM; Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA., Deans TL; Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA. Electronic address: tara.deans@utah.edu.
Jazyk: angličtina
Zdroj: Current opinion in biotechnology [Curr Opin Biotechnol] 2024 Jun; Vol. 87, pp. 103109. Date of Electronic Publication: 2024 Mar 24.
DOI: 10.1016/j.copbio.2024.103109
Abstrakt: Reprogramming cells will play a fundamental role in shaping the future of cell therapies by developing new strategies to engineer cells for improved performance and higher-order physiological functions. Approaches in synthetic biology harness cells' natural ability to sense diverse signals, integrate environmental inputs to make decisions, and execute complex behaviors based on the health of the organism or tissue. In this review, we highlight strategies in synthetic biology to reprogram cells, and discuss how recent approaches in the delivery of modified mRNA have created new opportunities to alter cell function in vivo. Finally, we discuss how combining concepts from synthetic biology and the delivery of mRNA in vivo could provide a platform for innovation to advance in vivo cellular reprogramming.
Competing Interests: Declaration of Competing Interest Nothing declared.
(Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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