| Autor: |
Nguyen TN; Department of Organic Chemistry, University of Science, Vietnam National University-Ho Chi Minh City, Ho Chi Minh City, Vietnam.; Department of Chemistry, Ho Chi Minh City University of Education, Ho Chi Minh City, Vietnam., Vo TN; Department of Chemical Technology, Ho Chi Minh City University of Technology and Education, Ho Chi Minh City, Vietnam., Nguyen KP; Department of Organic Chemistry, University of Science, Vietnam National University-Ho Chi Minh City, Ho Chi Minh City, Vietnam., Nguyen TH; Department of Organic Chemistry, University of Science, Vietnam National University-Ho Chi Minh City, Ho Chi Minh City, Vietnam., Nguyen TA; Department of Chemistry, Ho Chi Minh City University of Education, Ho Chi Minh City, Vietnam. |
| Jazyk: |
angličtina |
| Zdroj: |
Natural product research [Nat Prod Res] 2024 Mar 23, pp. 1-7. Date of Electronic Publication: 2024 Mar 23. |
| DOI: |
10.1080/14786419.2024.2330539 |
| Abstrakt: |
A new cucurbitacin, 3 β -( β -D-glucopyranosyloxy)-5 β ,6 β :16 α ,23 α -diepoxycucurbit-24-en-11-one or hygrocucurbin A (1) , along with two known compounds, including 3 β -( β -D-glucopyranosyloxy)-16 α ,23 α -epoxycucurbita-5,24-dien-11-one (2) and (+)-lyoniresinol (3) , were isolated from the bark of Elaeocarpus hygrophilus . Their chemical structures were elucidated by spectroscopic NMR, HR-IDA- TOF-MS analysis, and by comparison with the spectral data of corresponding compounds in the literature. Two cucurbitacins (1) and (2) were evaluated for their α -glucosidase inhibitory activity and cytotoxic against KB, MCF-7, Hep G2, and A549 cancer cell lines. For the α -glucosidase inhibitory activity, compound 1 showed an equivalent effect (IC 50 197.4 ± 4.1 µM) compared to the acarbose, a positive control (IC 50 208.5 ± 4.7 µM). And for the cytotoxicity, 2 was inactive while 1 was slightly sensitive against KB cells (IC 50 233.3 ± 2.5 µM). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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