Cure indicators and prevalence by stage at diagnosis for breast and colorectal cancer patients: A population-based study in Italy.

Autor: Dal Maso L; Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy., Toffolutti F; Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy., De Paoli A; Epidemiological Department, Azienda Zero, Padua, Italy., Giudici F; Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy., Francisci S; National Centre for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy., Bucchi L; Emilia-Romagna Cancer Registry, Romagna Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori, Meldola, Forlì, Italy., Zorzi M; Epidemiological Department, Azienda Zero, Padua, Italy., Fusco M; Registro Tumori ASL Napoli 3 Sud, Napoli, Italy., Caldarella A; Tuscany Cancer Registry, Institute for Cancer Research, Prevention and Clinical Network, Florence, Italy., Rossi S; Department of Oncology and Molecular Medicine, National Institute of Health, Rome, Italy., De Angelis R; Department of Oncology and Molecular Medicine, National Institute of Health, Rome, Italy., Botta L; Evaluative Epidemiology Unit, Department of Epidemiology and Data Science, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Ravaioli A; Emilia-Romagna Cancer Registry, Romagna Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori, Meldola, Forlì, Italy., Casella C; Liguria Cancer Registry, IRCCS Ospedale Policlinico San Martino, Genova, Italy., Musolino A; Emilia-Romagna Cancer Registry, Parma Unit, Medical Oncology Unit, University Hospital of Parma, Parma, Italy., Vitale MF; Registro Tumori ASL Napoli 3 Sud, Napoli, Italy., Mangone L; Emilia-Romagna Cancer Registry, Reggio Emilia Unit, Epidemiology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy., Fanetti AC; Sondrio Cancer Registry, Agenzia di Tutela della Salute della Montagna, Sondrio, Italy., Carpin E; Epidemiological Department, Azienda Zero, Padua, Italy., Burgio Lo Monaco MG; Coordination Centre of the Cancer Registry of Puglia-Strategic Regional Agency for Health and Social Care (AReSS), Bari, Italy., Migliore E; Piedmont Cancer Registry, Centro di Riferimento per l'Epidemiologia e la Prevenzione Oncologica (CPO) Piemonte and University of Turin, Turin, Italy., Gambino ML; Registro tumori ATS Insubria (Provincia di Como e Varese) S.S. Epidemiologia Registri Specializzati e Reti di Patologia, Varese, Italy., Ferrante M; Registro Tumori Integrato di Catania-Messina-Enna, Igiene Ospedaliera, Azienda Ospedaliero-Universitaria Policlinico G. Rodolico-San Marco, Catania, Italy., Stracci F; Umbria Cancer Registry, Public Health Section, Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Gasparotti C; Registro tumori ATS Brescia, Struttura Semplice Epidemiologia, ATS, Brescia, Italy., Carrozzi G; Emilia-Romagna Cancer Registry, Modena Unit, Public Health Department, Local Health Authority, Modena, Italy., Cavallo R; Cancer Registry Azienda Sanitaria Locale (ASL) Salerno, Dipartimento di Prevenzione, Salerno, Italy., Mazzucco W; Clinical Epidemiology and Cancer Registry Unit, Azienda Ospedaliera Universitaria Policlinico (AOUP) di Palermo, Palermo, Italy., Ballotari P; Osservatorio Epidemiologico, ATS Val Padana, Mantova, Italy., Ferretti S; Emilia-Romagna Cancer Registry, Ferrara Unit, Local Health Authority, Ferrara, University of Ferrara, Ferrara, Italy., Sampietro G; Bergamo Cancer Registry, Epidemiological Service, Agenzia di Tutela della Salute, Bergamo, Italy., Rizzello RV; Trento Province Cancer Registry, Unit of Clinical Epidemiology, Trento, Italy., Boschetti L; Cancer Registry of the Province of Pavia, Pavia, Italy., Cascone G; Azienda Sanitaria Provinciale (ASP) Ragusa-Dipartimento di Prevenzione-Registro Tumori, Ragusa, Italy., Mian M; Innovation, Research and Teaching Service (SABES-ASDAA), Lehrkrankenhaus der Paracelsus Medizinischen Privatuniversität, Bolzano-Bozen, Italy., Pesce MT; Monitoraggio Rischio Ambientale e Registro Tumori ASL Caserta, Caserta, Italy., Piras D; Nord Sardegna Cancer Registry, ASL, Sassari, Italy., Galasso R; Unit of Regional Cancer Registry, Clinical Epidemiology and Biostatistics, IRCCS Centro di Riferimento Oncologico di Basilicata (CROB), Rionero in Vulture, Italy., Bella F; Siracusa Cancer Registry, Provincial Health Authority of Siracusa, Siracusa, Italy., Seghini P; Emilia-Romagna Cancer Registry, Piacenza Unit, Public Health Department, AUSL Piacenza, Piacenza, Italy., Pinna P; Nuoro Cancer Registry, RT Nuoro, Servizio Igiene e Sanità Pubblica, ASL Nuoro, Nuoro, Italy., Crocetti E; Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy., Serraino D; Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy., Guzzinati S; Epidemiological Department, Azienda Zero, Padua, Italy.
Jazyk: angličtina
Zdroj: International journal of cancer [Int J Cancer] 2024 Jul 15; Vol. 155 (2), pp. 270-281. Date of Electronic Publication: 2024 Mar 23.
DOI: 10.1002/ijc.34923
Abstrakt: People alive many years after breast (BC) or colorectal cancer (CRC) diagnoses are increasing. This paper aimed to estimate the indicators of cancer cure and complete prevalence for Italian patients with BC and CRC by stage and age. A total of 31 Italian Cancer Registries (47% of the population) data until 2017 were included. Mixture cure models allowed estimation of net survival (NS); cure fraction (CF); time to cure (TTC, 5-year conditional NS >95%); cure prevalence (who will not die of cancer); and already cured (prevalent patients living longer than TTC). 2.6% of all Italian women (806,410) were alive in 2018 after BC and 88% will not die of BC. For those diagnosed in 2010, CF was 73%, 99% when diagnosed at stage I, 81% at stage II, and 36% at stages III-IV. For all stages combined, TTC was >10 years under 45 and over 65 years and for women with advanced stages, but ≤1 year for all BC patients at stage I. The proportion of already cured prevalent BC women was 75% (94% at stage I). Prevalent CRC cases were 422,407 (0.7% of the Italian population), 90% will not die of CRC. For CRC patients, CF was 56%, 92% at stage I, 71% at stage II, and 35% at stages III-IV. TTC was ≤10 years for all age groups and stages. Already cured were 59% of all prevalent CRC patients (93% at stage I). Cancer cure indicators by stage may contribute to appropriate follow-up in the years after diagnosis, thus avoiding patients' discrimination.
(© 2024 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.)
Databáze: MEDLINE
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