Pharmacokinetic characteristics of florfenicol in green sea turtles (Chelonia mydas) and hawksbill sea turtles (Eretmochelys imbricata) after intramuscular administration.

Autor: Sitthiangkool P; Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand., Poapolathep A; Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand., Chomcheun T; Eastern Marine and Coastal Resources Research and Development Center, Rayong, Thailand., Jongkolpath O; Eastern Marine and Coastal Resources Research and Development Center, Rayong, Thailand., Khidkhan K; Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand., Klangkaew N; Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand., Phaochoosak N; Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand., Giorgi M; Department of Veterinary Sciences, University of Pisa, San Piero a Grado, Italy., Poapolathep S; Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand.
Jazyk: angličtina
Zdroj: Journal of veterinary pharmacology and therapeutics [J Vet Pharmacol Ther] 2024 Jul; Vol. 47 (4), pp. 300-307. Date of Electronic Publication: 2024 Mar 22.
DOI: 10.1111/jvp.13441
Abstrakt: The pharmacokinetics of florfenicol (FFC) in green sea and hawksbill sea turtles were evaluated following intramuscular (i.m.) administration at two different dosages of 20 or 30 mg/kg body weight (b.w.). This study (longitudinal design) used 5 green sea and 5 hawksbill sea turtles for the two dosages. Blood samples were collected at assigned times up to 168 h. FFC plasma samples were analyzed using validated high-performance liquid chromatography equipped with diode array detection. The pharmacokinetic analysis was performed using a non-compartment approach. The FFC plasma concentrations increased with the dosage. The elimination half-life was similar between the treatment groups (range 19-25 h), as well as the plasma protein binding (range 18.59%-20.65%). According to the surrogate PK/PD parameter (T > MIC, 2 μg/mL), the 20 and 30 mg/kg dosing rates should be effective doses for susceptible bacterial infections in green sea and hawksbill sea turtles.
(© 2024 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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