Association between Mediterranean diet and dementia and Alzheimer disease: a systematic review with meta-analysis.

Autor: Nucci D; Struttura Semplice Dipartimentale Igiene Alimenti E Nutrizione, Dipartimento Di Igiene E Prevenzione Sanitaria, Azienda Di Tutela Della Salute (ATS) Brescia, Via Duca Degli Abruzzi, 15, 25124, Brescia, Italy., Sommariva A; Department of Biomedical Sciences for Health, University of Milan, Via Pascal, 36, 20133, Milan, Italy., Degoni LM; Department of Biomedical Sciences for Health, University of Milan, Via Pascal, 36, 20133, Milan, Italy., Gallo G; Department of Biomedical Sciences for Health, University of Milan, Via Pascal, 36, 20133, Milan, Italy., Mancarella M; Department of Biomedical Sciences for Health, University of Milan, Via Pascal, 36, 20133, Milan, Italy., Natarelli F; Department of Biomedical Sciences for Health, University of Milan, Via Pascal, 36, 20133, Milan, Italy., Savoia A; Department of Biomedical Sciences for Health, University of Milan, Via Pascal, 36, 20133, Milan, Italy., Catalini A; Department of Biomedical Sciences and Public Health, Università Politecnica Delle Marche, Via Tronto 10/a, 60100, Ancona, Italy., Ferranti R; Struttura Semplice Dipartimentale Igiene Alimenti E Nutrizione, Dipartimento Di Igiene E Prevenzione Sanitaria, Azienda Di Tutela Della Salute (ATS) Brescia, Via Duca Degli Abruzzi, 15, 25124, Brescia, Italy., Pregliasco FE; Department of Biomedical Sciences for Health, University of Milan, Via Pascal, 36, 20133, Milan, Italy., Castaldi S; Department of Biomedical Sciences for Health, University of Milan, Via Pascal, 36, 20133, Milan, Italy.; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy., Gianfredi V; Department of Biomedical Sciences for Health, University of Milan, Via Pascal, 36, 20133, Milan, Italy. vincenza.gianfredi@unimi.it.
Jazyk: angličtina
Zdroj: Aging clinical and experimental research [Aging Clin Exp Res] 2024 Mar 22; Vol. 36 (1), pp. 77. Date of Electronic Publication: 2024 Mar 22.
DOI: 10.1007/s40520-024-02718-6
Abstrakt: Background: Dementia affects 5-8% of the population aged over 65 years (~50 million worldwide). Several factors are associated with increased risk, including diet. The Mediterranean diet (MedDiet) has shown potential protective effects against several chronic diseases.
Aims: This systematic review with meta-analysis aim was to assess the association between adherence to the MedDiet and the risk of dementia in the elderly.
Methods: PRISMA-2020 guidelines were followed. PubMed/MEDLINE and Scopus were searched on 17 July 2023. The Newcastle-Ottawa Scale tool was used to assess the risk of bias. The protocol was pre-registered in PROSPERO (registration number: CRD 42023444368). Heterogeneity was assessed using the I 2 test. Publication bias was assessed by visual inspection of the funnel plot and by Egger's regression asymmetry test. The final effect size was reported as OR or HR, depending on the study design of the included studies.
Results: Out of 682 records, 21 were included in the analysis. The pooled OR was 0.89 (95% CI = 0.84-0.94) based on 65,955 participants (I 2  = 69.94). When only cohort studies were included, HR was 0.84 (95% CI = 0.76-0.94) based on 55,205 participants (I 2  = 89.70). When only Alzheimer Disease was considered OR was 0.73 (95% CI = 0.62-0.85) based on 38,292 participants (I 2  = 63.85).
Discussion: Despite the relatively low risk reduction associated with higher adherence to MedDiet among elderly, it should be considered that this population is the most affected.
Conclusions: Adherence to MedDiet could be an effective non-pharmacological measure to reduce the burden of dementia, even among elderly.
(© 2024. The Author(s).)
Databáze: MEDLINE
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