Primitive purine biosynthesis connects ancient geochemistry to modern metabolism.

Autor: Goldford JE; Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA, USA. goldford@caltech.edu.; Physics of Living Systems, Massachusetts Institute of Technology, Cambridge, MA, USA. goldford@caltech.edu.; Blue Marble Space Institute of Science, Seattle, WA, USA. goldford@caltech.edu., Smith HB; Blue Marble Space Institute of Science, Seattle, WA, USA.; Earth-Life Science Institute, Tokyo Institute of Technology, Tokyo, Japan., Longo LM; Blue Marble Space Institute of Science, Seattle, WA, USA.; Earth-Life Science Institute, Tokyo Institute of Technology, Tokyo, Japan., Wing BA; Department of Geological Sciences, University of Colorado, Boulder, CO, USA., McGlynn SE; Blue Marble Space Institute of Science, Seattle, WA, USA. mcglynn@elsi.jp.; Earth-Life Science Institute, Tokyo Institute of Technology, Tokyo, Japan. mcglynn@elsi.jp.; Biofunctional Catalyst Research Team, RIKEN Center for Sustainable Resource Science, Wako, Japan. mcglynn@elsi.jp.
Jazyk: angličtina
Zdroj: Nature ecology & evolution [Nat Ecol Evol] 2024 May; Vol. 8 (5), pp. 999-1009. Date of Electronic Publication: 2024 Mar 22.
DOI: 10.1038/s41559-024-02361-4
Abstrakt: An unresolved question in the origin and evolution of life is whether a continuous path from geochemical precursors to the majority of molecules in the biosphere can be reconstructed from modern-day biochemistry. Here we identified a feasible path by simulating the evolution of biosphere-scale metabolism, using only known biochemical reactions and models of primitive coenzymes. We find that purine synthesis constitutes a bottleneck for metabolic expansion, which can be alleviated by non-autocatalytic phosphoryl coupling agents. Early phases of the expansion are enriched with enzymes that are metal dependent and structurally symmetric, supporting models of early biochemical evolution. This expansion trajectory suggests distinct hypotheses regarding the tempo, mode and timing of metabolic pathway evolution, including a late appearance of methane metabolisms and oxygenic photosynthesis consistent with the geochemical record. The concordance between biological and geological analyses suggests that this trajectory provides a plausible evolutionary history for the vast majority of core biochemistry.
(© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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