Evaluation of IVIM in the Spinal Cord of Multiple Sclerosis Patients.
| Autor: | Johnson B; Brian Johnson, PhD, R.T.(MR)(N), CNMT, works for Philips in Cleveland, Ohio, and the Department of Radiology at the University of Texas Southwestern Medical Center in Dallas., Heales C; Christine Heales, PhD, works for the Department of Health and Care Professions, Faculty of Health and Life Sciences at the University of Exeter, United Kingdom. |
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| Jazyk: | angličtina |
| Zdroj: | Radiologic technology [Radiol Technol] 2024 Mar; Vol. 95 (4), pp. 248-255. |
| Abstrakt: | Purpose: To evaluate the ability of intravoxel incoherent motion (IVIM), a perfusion-weighted imaging technique, to differentiate microcirculation changes in the spinal cord of patients with multiple sclerosis (MS) compared with healthy individuals. Methods: Fifteen healthy individuals and 15 individuals with MS underwent IVIM magnetic resonance (MR) imaging using a 3 T scanner with 2-D axial gradient recalled echo and 2-D axial diffusion-weighted imaging (DWI) sequences. The MR images underwent segmentation to produce white matter and gray matter regions of interest. IVIM metrics for perfusion fraction, pseudo-diffusion coefficients, water-diffusion coefficients, and signal without diffusion encoding were calculated using DWI data. An unpaired t test was performed on these IVIM metrics to compare imaging of healthy individuals with imaging of individuals with MS. Results: No significant differences between images from healthy individuals and individuals with MS were found for any IVIM metric. The lowest P values calculated (.082 and .055) were in the white matter region of interest perfusion fraction and pseudo-diffusion measurements. The gray matter region of interest had the highest P value. Discussion: The findings in this study are consistent with current perfusion-weighted imaging literature focused on MS in the brain. The gray matter in MS patients in this study showed reduced perfusion compared with healthy individuals. Conclusion: IVIM is a promising imaging technique for the evaluation of the spinal cord in MS patients. It has the potential to provide valuable information on microvascular perfusion and diffusion in the spinal cord, which might be related to disease progression and response to treatment. (© 2024 American Society of Radiologic Technologists.) |
| Databáze: | MEDLINE |
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