Prevalence of fatigue and cognitive impairment after traumatic brain injury.

Autor: Wright TJ; Department of Internal Medicine, The University of Texas Medical Branch, Galveston, Texas, United States of America., Elliott TR; Department of Educational Psychology, Texas A&M University, College Station, Texas, United States of America., Randolph KM; Department of Internal Medicine, The University of Texas Medical Branch, Galveston, Texas, United States of America., Pyles RB; Department of Pediatrics, The University of Texas Medical Branch, Galveston, Texas, United States of America., Masel BE; Department of Neurology, The University of Texas Medical Branch, Galveston, Texas, United States of America.; Centre for Neuro Skills, Bakersfield, California, United States of America., Urban RJ; Department of Internal Medicine, The University of Texas Medical Branch, Galveston, Texas, United States of America., Sheffield-Moore M; Department of Internal Medicine, The University of Texas Medical Branch, Galveston, Texas, United States of America.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Mar 22; Vol. 19 (3), pp. e0300910. Date of Electronic Publication: 2024 Mar 22 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0300910
Abstrakt: Background: Following traumatic brain injury (TBI) some patients develop lingering comorbid symptoms of fatigue and cognitive impairment. The mild cognitive impairment self-reported by patients is often not detected with neurocognitive tests making it difficult to determine how common and severe these symptoms are in individuals with a history of TBI. This study was conducted to determine the relative prevalence of fatigue and cognitive impairment in individuals with a history of TBI.
Methods: The Fatigue and Altered Cognition Scale (FACs) digital questionnaire was used to assess self-reported fatigue and cognitive impairment. Adults aged 18-70 were digitally recruited for the online anonymous study. Eligible participants provided online consent, demographic data, information about lifetime TBI history, and completed the 20 item FACs questionnaire.
Results: A total of 519 qualifying participants completed the online digital study which included 204 participants with a history of TBI of varied cause and severity and 315 with no history of TBI. FACs Total Score was significantly higher in the TBI group (57.7 ± 22.2) compared to non-TBI (39.5 ± 23.9; p<0.0001) indicating more fatigue and cognitive impairment. When stratified by TBI severity, FACs score was significantly higher for all severity including mild (53.9 ± 21.9, p<0.0001), moderate (54.8 ± 24.4, p<0.0001), and severe (59.7 ± 20.9, p<0.0001) TBI. Correlation analysis indicated that more severe TBI was associated with greater symptom severity (p<0.0001, r = 0.3165). Ancillary analysis also suggested that FACs scores may be elevated in participants with prior COVID-19 infection but no history of TBI.
Conclusions: Adults with a history of even mild TBI report significantly greater fatigue and cognitive impairment than those with no history of TBI, and symptoms are more profound with greater TBI severity.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Wright et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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