Cross-sectional study of influenza trends and costs in Malaysia between 2016 and 2018.

Autor: Wan Puteh SE; Department of Community Health, Pusat Perubatan Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia., Aazmi MS; School of Biology, Faculty of Applied Sciences, Universiti Teknologi MARA, Shah Alam, Selangor, Malaysia., Aziz MN; Lablink (M) Sdn. Bhd, Kuala Lumpur, Malaysia., Kamarudin N'; Department of Community Health, Pusat Perubatan Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia., Sam JI; Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia., Thayan R; Infectious Disease Research Centre, Institute for Medical Research, Ministry of Health Malaysia, Putrajaya, Malaysia., Wan Mahiyuddin WR; Environmental Health Research Centre, Institute for Medical Research, Ministry of Health Malaysia, Putrajaya, Malaysia., Wan Mohamed Noor WN; Disease Control Division, Ministry of Health Malaysia, Putrajaya, Malaysia., Cheong A; Medical Department, Sanofi, Petaling Jaya, Malaysia., El Guerche-Séblain C; Global Vaccine Epidemiology and Modelling Department, Sanofi, Singapore, Singapore., Khor J; Medical Department, Sanofi, Petaling Jaya, Malaysia., Zamri EN; Infectious Disease Research Centre, Institute for Medical Research, Ministry of Health Malaysia, Putrajaya, Malaysia., Lam JY; Department of Medical Microbiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia., Sekawi Z; Department of Medical Microbiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Mar 22; Vol. 19 (3), pp. e0301068. Date of Electronic Publication: 2024 Mar 22 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0301068
Abstrakt: Background and Objectives: While influenza circulates year-round in Malaysia, research data on its incidence is scarce. Yet, this information is vital to the improvement of public health through evidence-based policies. In this cross-sectional study, we aimed to determine the trends and financial costs of influenza.
Methods: Data for the years 2016 through 2018 were gathered retrospectively from several sources. These were existing Ministry of Health (MOH) influenza sentinel sites data, two teaching hospitals, and two private medical institutions in the Klang Valley, Malaysia. Expert consensus determined the final estimates of burden for laboratory-confirmed influenza-like illness (ILI) and severe acute respiratory infection (SARI). Economic burden was estimated separately using secondary data supplemented by MOH casemix costing.
Results: Altogether, data for 11,652 cases of ILI and 5,764 cases of SARI were extracted. The influenza B subtype was found to be predominant in 2016, while influenza A was more prevalent in 2017 and 2018. The distribution timeline revealed that the highest frequency of cases occurred in March and April of all three years. The costs of influenza amounted to MYR 310.9 million over the full three-year period.
Conclusions: The study provides valuable insights into the dynamic landscape of influenza in Malaysia. The findings reveal a consistent year-round presence of influenza with irregular seasonal peaks, including a notable influenza A epidemic in 2017 and consistent surges in influenza B incidence during March across three years. These findings underscore the significance of continuous monitoring influenza subtypes for informed healthcare strategies as well as advocate for the integration of influenza vaccination into Malaysia's national immunization program, enhancing overall pandemic preparedness.
Competing Interests: Three authors (Adelina Cheong, Clotilde El Guerche-Séblain, and Jean Khor) are employees of Sanofi Pasteur and may hold shares and/or stock options in the company. All other authors report no potential conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
(Copyright: © 2024 Wan Puteh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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