Indole-containing pharmaceuticals: targets, pharmacological activities, and SAR studies.
| Autor: | Zeng W; School of Pharmaceutical Science and Technology, Tianjin University Tianjin 300072 China duyunfeier@tju.edu.cn., Han C; School of Pharmaceutical Science and Technology, Tianjin University Tianjin 300072 China duyunfeier@tju.edu.cn., Mohammed S; School of Pharmaceutical Science and Technology, Tianjin University Tianjin 300072 China duyunfeier@tju.edu.cn., Li S; School of Pharmaceutical Science and Technology, Tianjin University Tianjin 300072 China duyunfeier@tju.edu.cn., Song Y; Department of Chemical Engineering & Biotechnology, University of Cambridge CB2 3RA Cambridge UK., Sun F; Research Center for Chemical Safety & Security and Verification Technology & College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology Shijiazhuang 050018 China fxsun001@163.com., Du Y; School of Pharmaceutical Science and Technology, Tianjin University Tianjin 300072 China duyunfeier@tju.edu.cn. |
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| Jazyk: | angličtina |
| Zdroj: | RSC medicinal chemistry [RSC Med Chem] 2024 Jan 30; Vol. 15 (3), pp. 788-808. Date of Electronic Publication: 2024 Jan 30 (Print Publication: 2024). |
| DOI: | 10.1039/d3md00677h |
| Abstrakt: | Indole is a prestigious heterocyclic skeleton widely found in both naturally-occurring and biologically-active compounds. Pharmaceutical agents containing an indole skeleton in their framework possess a wide range of pharmacological properties, including antiviral, antitumor, analgesic, and other therapeutic activities, and many indole-containing drugs have been proven to have excellent pharmacokinetic and pharmacological effects. Over the past few decades, the FDA has approved over 40 indole-containing drugs for the treatment of various clinical conditions, and the development of indole-related drugs has attracted significant attention from medicinal chemists. This review aims to provide an overview of all the approved drugs that contain an indole nucleus, focusing on their targets, pharmacological activities, and SAR studies. Competing Interests: There are no conflicts to declare. (This journal is © The Royal Society of Chemistry.) |
| Databáze: | MEDLINE |
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