Advanced liver fibrosis is associated with decreased gait speed in older patients with chronic liver disease.

Autor: Fudeyasu K; Division of Rehabilitation, Department of Clinical Practice and Support, Hiroshima University Hospital, Hiroshima, Japan., Ushio K; Department of Rehabilitation Medicine, Hiroshima University Hospital, Hiroshima, Japan. ushiosista@hiroshima-u.ac.jp., Nomura T; Department of Physical Therapy, Faculty of Rehabilitation, Kansai Medical University, Osaka, Japan., Kawae T; Department of Physical Therapy, Makuhari Human Care Faculty, Tohto University, Chiba, Japan., Iwaki D; Division of Rehabilitation, Department of Clinical Practice and Support, Hiroshima University Hospital, Hiroshima, Japan., Nakashima Y; Division of Rehabilitation, Department of Clinical Practice and Support, Hiroshima University Hospital, Hiroshima, Japan., Nagao A; Division of Nutrition Management, Hiroshima University Hospital, Hiroshima, Japan., Hiramatsu A; Department of Gastroenterology, KKR Hiroshima Memorial Hospital, Hiroshima, Japan., Murakami E; Department of Gastroenterology, Hiroshima University Hospital, Hiroshima, Japan., Oka S; Department of Gastroenterology, Hiroshima University Hospital, Hiroshima, Japan., Mikami Y; Department of Rehabilitation Medicine, Hiroshima University Hospital, Hiroshima, Japan.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Mar 21; Vol. 14 (1), pp. 6809. Date of Electronic Publication: 2024 Mar 21.
DOI: 10.1038/s41598-024-57342-1
Abstrakt: This study investigated whether the progression of liver fibrosis affects the prevalence of sarcopenia and incidence of decreased gait speed in older patients with chronic liver disease (CLD). Patients with CLD aged ≥ 60 years were classified into low, intermediate, and high fibrosis 4 (FIB-4) index groups according to the degree of liver fibrosis. The prevalence of sarcopenia and incidence of decreased gait speed (< 1.0 m/s) were compared among the three groups. Logistic regression analysis was performed to investigate factors affecting the risk of decreased gait speed. No significant difference was observed in the prevalence of sarcopenia among the three groups, but the incidence of decreased gait speed significantly differed (p = 0.029). When analyzed individually, a significant difference in decreased gait speed incidence was observed between the high and low FIB-4 index groups (p = 0.014). In logistic regression analysis, the progression of liver fibrosis (odds ratio: 1.32, 95% confidence interval: 1.13-1.55) and lower extremity muscle strength (LEMS) (odds ratio: 0.92, 95% confidence interval: 0.88-0.97) were significantly associated with decreased gait speed. As liver fibrosis progresses in older patients with CLD, it becomes important to focus on not only skeletal muscle mass and grip strength, but also gait speed and LEMS.
(© 2024. The Author(s).)
Databáze: MEDLINE
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