Is it time for a precision health approach to the management of newborn hyperbilirubinemia?

Autor: Stevenson DK; Department of Pediatrics, Division of Neonatal & Developmental Medicine, Stanford University School of Medicine, Stanford, CA, USA. dstevenson@stanford.edu., Wells GS; Stanford Maternal & Child Health Research Institute, Stanford University School of Medicine, Stanford, CA, USA., Wong RJ; Department of Pediatrics, Division of Neonatal & Developmental Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Jazyk: angličtina
Zdroj: Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2024 Jun; Vol. 44 (6), pp. 920-923. Date of Electronic Publication: 2024 Mar 21.
DOI: 10.1038/s41372-024-01941-3
Abstrakt: Newborn hyperbilirubinemia during the first two weeks of life is one of most common problems requiring management decisions by a pediatrician. However, high bilirubin levels in the circulation have been associated with neurologic injury under a variety of conditions encountered in the newborn infant, such as hemolysis. The risk for developing dangerous hyperbilirubinemia is multifactorial and is determined by a complex set of factors related to a newborn infant's genetic capacities as well as intra- and extrauterine exposures. To this end, a precision health approach based on the integration of prenatal genetic and postnatal diagnostic measures might improve the management of neonatal hyperbilirubinemia.
(© 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.)
Databáze: MEDLINE
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