Longitudinal aortic strain, ventriculo-arterial coupling and fatty acid oxidation: novel insights into human cardiovascular aging.

Autor: Zhang H; National Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore.; Department of Cardiology, the First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, China., Leng S; National Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore.; Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore., Gao F; National Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore.; Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore., Kovalik JP; Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore.; Singapore General Hospital, 31 Third Hospital Ave, Singapore, 168753, Singapore., Tan RS; National Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore.; Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore., Wee HN; Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore., Chua KV; Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore., Ching J; Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore.; KK Women's and Children's Hospital, 100 Bukit Timah Rd, Singapore, 229899, Singapore., Zhao X; National Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore., Allen J; Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore., Wu Q; Department of Cardiology, the Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang, 330006, China., Leiner T; Department of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN, USA., Zhong L; National Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore. zhong.liang@duke-nus.edu.sg.; Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore. zhong.liang@duke-nus.edu.sg., Koh AS; National Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore. angela.koh.s.m@singhealth.com.sg.; Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore. angela.koh.s.m@singhealth.com.sg.
Jazyk: angličtina
Zdroj: GeroScience [Geroscience] 2024 Dec; Vol. 46 (6), pp. 5459-5471. Date of Electronic Publication: 2024 Mar 22.
DOI: 10.1007/s11357-024-01127-x
Abstrakt: Aging-induced aortic stiffness has been associated with altered fatty acid metabolism. We studied aortic stiffness using cardiac magnetic resonance (CMR)-assessed ventriculo-arterial coupling (VAC) and novel aortic (AO) global longitudinal strain (GLS) combined with targeted metabolomic profiling. Among community older adults without cardiovascular disease, VAC was calculated as aortic pulse wave velocity (PWV), a marker of arterial stiffness, divided by left ventricular (LV) GLS. AOGLS was the maximum absolute strain measured by tracking the phasic distance between brachiocephalic artery origin and aortic annulus. In 194 subjects (71 ± 8.6 years; 88 women), AOGLS (mean 5.6 ± 2.1%) was associated with PWV (R = -0.3644, p < 0.0001), LVGLS (R = 0.2756, p = 0.0001) and VAC (R = -0.3742, p <0.0001). Stiff aorta denoted by low AOGLS <4.26% (25 th percentile) was associated with age (OR 1.13, 95% CI 1.04-1.24, p = 0.007), body mass index (OR 1.12, 95% CI 1.01-1.25, p = 0.03), heart rate (OR 1.04, 95% CI 1.01-1.06, p = 0.011) and metabolites of medium-chain fatty acid oxidation: C8 (OR 1.005, p = 0.026), C10 (OR 1.003, p = 0.036), C12 (OR 1.013, p = 0.028), C12:2-OH/C10:2-DC (OR 1.084, p = 0.032) and C16-OH (OR 0.82, p = 0.006). VAC was associated with changes in long-chain hydroxyl and dicarboxyl carnitines. Multivariable models that included acyl-carnitine metabolites, but not amino acids, significantly increased the discrimination over clinical risk factors for prediction of AOGLS (AUC [area-under-curve] 0.73 to 0.81, p = 0.037) and VAC (AUC 0.78 to 0.87, p = 0.0044). Low AO GLS and high VAC were associated with altered medium-chain and long-chain fatty acid oxidation, respectively, which may identify early metabolic perturbations in aging-associated aortic stiffening. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02791139.
(© 2024. The Author(s), under exclusive licence to American Aging Association.)
Databáze: MEDLINE
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