Second-order scattering sensor based on the Zn 0.97 La 0.03 O compound for selective and stable detection of glycated albumin.

Autor: Dos Santos JJS; Garanhuns Campus, University of Pernambuco (UPE), Garanhuns 55294-902, PE, Brazil., Garcia RRP; Graduate Program in Materials Science and Engineering, Federal University of Piauí (UFPI), Teresina 64049-550, PI, Brazil; Engineering Campus - Academic Unit of Cabo de Santo Agostinho, Federal Rural University of Pernambuco (UFRPE), Cabo de Santo Agostinho 54518-430, PE, Brazil., Soares AS; Graduate Program in Materials Science and Engineering, Federal University of Piauí (UFPI), Teresina 64049-550, PI, Brazil., de Amorim Silva EG; Department of Fundamental Chemistry, Federal University of Pernambuco (UFPE), Recife 50670-901, PE, Brazil., Neves JL; Department of Fundamental Chemistry, Federal University of Pernambuco (UFPE), Recife 50670-901, PE, Brazil., Menezes TM; Engineering Campus - Academic Unit of Cabo de Santo Agostinho, Federal Rural University of Pernambuco (UFRPE), Cabo de Santo Agostinho 54518-430, PE, Brazil. Electronic address: thais.meira@ufrpe.br.
Jazyk: angličtina
Zdroj: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2024 Jun 05; Vol. 314, pp. 124176. Date of Electronic Publication: 2024 Mar 19.
DOI: 10.1016/j.saa.2024.124176
Abstrakt: Here, we presented a second-order scattering sensor based on the Zn 0.97 La 0.03 O compound (LaZnO) for selective and stable detection of glycated albumin (GA, glycemic long-term biomarker). The LaZnO sample was obtained through the co-precipitation method and then characterized using microscopic and spectroscopic techniques. Furthermore, the selectivity, molecular interference, temporal stability, and pH effects of the LaZnO SOS signal in the absence and presence of GA were investigated. The results indicate the stability of the SOS signal over more than 60 days. Assays conducted within the pH range of 5 to 8 indicate that the detection of GA remains unaffected under the given conditions. Selectivity studies show that the SOS signal of LaZnO is reduced only upon contact with GA, while interference studies show that detection is not affected by other chemical species. Additionally, the calibration curve test showed high sensitivity of the material, with a detection limit of 0.55 µg/ml. All the results suggest that LaZnO can deliver efficiency, selectivity, accuracy, and fast response as a GA biosensor, emphasizing LaZnO's usefulness in detecting protein biomarkers.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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