Repeated co-option of HMG-box genes for sex determination in brown algae and animals.

Autor: Luthringer R; Department of Algal Development and Evolution, Max Planck Institute for Biology Tübingen, 72076 Tübingen, Germany., Raphalen M; Department of Algal Development and Evolution, Max Planck Institute for Biology Tübingen, 72076 Tübingen, Germany., Guerra C; Department of Algal Development and Evolution, Max Planck Institute for Biology Tübingen, 72076 Tübingen, Germany., Colin S; Department of Algal Development and Evolution, Max Planck Institute for Biology Tübingen, 72076 Tübingen, Germany., Martinho C; Department of Algal Development and Evolution, Max Planck Institute for Biology Tübingen, 72076 Tübingen, Germany., Zheng M; Department of Algal Development and Evolution, Max Planck Institute for Biology Tübingen, 72076 Tübingen, Germany., Hoshino M; Department of Algal Development and Evolution, Max Planck Institute for Biology Tübingen, 72076 Tübingen, Germany.; Research Center for Inland Seas, Kobe University, Kobe 658-0022, Japan., Badis Y; Roscoff Biological Station, CNRS-Sorbonne University, Place Georges Teissier, 29680 Roscoff, France., Lipinska AP; Department of Algal Development and Evolution, Max Planck Institute for Biology Tübingen, 72076 Tübingen, Germany., Haas FB; Department of Algal Development and Evolution, Max Planck Institute for Biology Tübingen, 72076 Tübingen, Germany., Barrera-Redondo J; Department of Algal Development and Evolution, Max Planck Institute for Biology Tübingen, 72076 Tübingen, Germany., Alva V; Department of Protein Evolution, Max Planck Institute for Biology Tübingen, 72076 Tübingen, Germany., Coelho SM; Department of Algal Development and Evolution, Max Planck Institute for Biology Tübingen, 72076 Tübingen, Germany.
Jazyk: angličtina
Zdroj: Science (New York, N.Y.) [Science] 2024 Mar 22; Vol. 383 (6689), pp. eadk5466. Date of Electronic Publication: 2024 Mar 22.
DOI: 10.1126/science.adk5466
Abstrakt: In many eukaryotes, genetic sex determination is not governed by XX/XY or ZW/ZZ systems but by a specialized region on the poorly studied U (female) or V (male) sex chromosomes. Previous studies have hinted at the existence of a dominant male-sex factor on the V chromosome in brown algae, a group of multicellular eukaryotes distantly related to animals and plants. The nature of this factor has remained elusive. Here, we demonstrate that an HMG-box gene acts as the male-determining factor in brown algae, mirroring the role HMG-box genes play in sex determination in animals. Over a billion-year evolutionary timeline, these lineages have independently co-opted the HMG box for male determination, representing a paradigm for evolution's ability to recurrently use the same genetic "toolkit" to accomplish similar tasks.
Databáze: MEDLINE
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