| Autor: |
Nitu; Department of Physics, Indian Institute of Technology Guwahati, Guwahati 781039, India. asrini@iitg.ac.in., Fopase R; Bio-Interface & Environmental Engineering Lab, Department of Biosciences and Bioengineering, Indian Institute of Technology, Guwahati, Guwahati 781039, India., Pandey LM; Bio-Interface & Environmental Engineering Lab, Department of Biosciences and Bioengineering, Indian Institute of Technology, Guwahati, Guwahati 781039, India., Hazarika KP; Department of Science and Humanities, National Institute of Technology Nagaland, 797103, India., Borah JP; Department of Science and Humanities, National Institute of Technology Nagaland, 797103, India., Singh RK; Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, 31116, Republic of Korea., Srinivasan A; Department of Physics, Indian Institute of Technology Guwahati, Guwahati 781039, India. asrini@iitg.ac.in. |
| Abstrakt: |
Magnetite (Fe 3 O 4 ) nanoparticle (MNP)-substituted glass-ceramic (MSGC) powders with compositions of (45 - x )SiO 2 -24.5CaO-24.5Na 2 O-6P 2 O 5 - x Fe 3 O 4 ( x = 5, 8, and 10 wt%) have been prepared by a sol-gel route by introducing Fe 3 O 4 nanoparticles during the synthesis. The X-ray diffraction patterns of the as-prepared MSGC nanopowders revealed the presence of combeite (Na 2 Ca 2 Si 3 O 9 ), magnetite, and sodium nitrate (NaNO 3 ) crystalline phases. Heat-treatment up to 700 °C for 1 h resulted in the complete dissolution of NaNO 3 along with partial conversion of magnetite into hematite (α-Fe 2 O 3 ). Optimal heat-treatment of the MSGC powders at 550 °C for 1 h yielded the highest relative percentage of magnetite (without hematite) with some residual NaNO 3 . The saturation magnetization and heat generation capacity of the MSGC fluids increased with an increase in the MNP content. The in vitro bioactivity of the MSGC pellets was evaluated by monitoring the pH and the formation of a hydroxyapatite surface layer upon immersion in modified simulated body fluid. Proliferation of MG-63 osteoblast cells indicated that all of the MSGC compositions were non-toxic and MSGC with 10 wt% MNPs exhibited extraordinarily high cell viability. The MSGC with 10 wt% MNPs demonstrated optimal characteristics in terms of cell viability, magnetic properties, and induction heating capacity, which surpass those of the commercial magnetic fluid FluidMag-CT employed in hyperthermia treatment. |
