Biocatalytic enantioselective synthesis of cenobamate, an antiepileptic drug.

Autor: Haritha V; Research Scholar, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu, India.; Fluoro-Agrochemicals, CSIR-Indian Institute of Chemical Technology, Hyderabad, India., Deepthi P; Fluoro-Agrochemicals, CSIR-Indian Institute of Chemical Technology, Hyderabad, India., Gundamalla R; Fluoro-Agrochemicals, CSIR-Indian Institute of Chemical Technology, Hyderabad, India., Nagesh K; Fluoro-Agrochemicals, CSIR-Indian Institute of Chemical Technology, Hyderabad, India., Satyanarayana SV; Department of Chemical Engineering, JNTUA College of Engineering, Ananthapuramu, Constituent College of Jawaharlal Nehru Technological University Anantapur, Ananthapuramu, India., Rao AB; Fluoro-Agrochemicals, CSIR-Indian Institute of Chemical Technology, Hyderabad, India., Balasubramanian S; Center for X-ray Crystallography, CSIR-Indian Institute of Chemical Technology, Hyderabad, India., Reddy BVS; Fluoro-Agrochemicals, CSIR-Indian Institute of Chemical Technology, Hyderabad, India.
Jazyk: angličtina
Zdroj: Chirality [Chirality] 2024 Apr; Vol. 36 (4), pp. e23660.
DOI: 10.1002/chir.23660
Abstrakt: A green and efficient process for the synthesis of cenobamate has been accomplished in 70% yield and >99% ee through the bio-reduction of β-ketotetrazole using Daucus carota whole plant cells. The corresponding β-hydroxytetrazole was isolated in 60% yield and >98% ee. This is the first report on the biocatalytic reduction of β-ketotetrazole using plant enzymes derived from D. carota root cells with excellent enantioselectivity.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
Externí odkaz: