Bipolar symptoms, somatic burden and functioning in older-age bipolar disorder: A replication study from the global aging & geriatric experiments in bipolar disorder database (GAGE-BD) project.

Autor: Sajatovic M; Case Western Reserve University School of Medicine, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA., Rej S; Jewish General Hospital/Lady Davis Hospital, McGill University, Montreal, Québec, Canada., Almeida OP; University of Western Australia, Perth, Western Australia, Australia., Altinbas K; Selçuk University Medical Faculty, Department of Psychiatry, Mazhar Osman Mood Clinic, Konya, Turkey., Balanzá-Martínez V; Teaching Unit of Psychiatry and Psychological Medicine, Department of Medicine, University of Valencia, CIBERSAM, Valencia, Spain., Barbosa IG; Mental Health Department, Medicine School, Minas Gerais University, Belo Horizonte, Brazil., Beunders AJM; GGZ inGeest, Amsterdam UMC, Vrije Universiteit Amsterdam, Psychiatry, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands., Blumberg HP; Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA., Briggs FBS; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Dols A; Amsterdam UMC, VU University, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Department of Psychiatry, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands., Forester BP; Division of Geriatric Psychiatry, McLean Hospital, Belmont, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA., Forlenza OV; Laboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, HCFMUSP, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Gildengers AG; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Jimenez E; Bipolar and Depressive Disorders Unit, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, ISCIII Barcelona, Barcelona, Catalonia, Spain., Klaus F; Department of Psychiatry, University of California, San Diego, California, USA., Lafer B; Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil., Mulsant B; Department of Psychiatry, University of Toronto, Center for Addiction & Mental Health, Toronto, Ontario, Canada., Mwangi B; Department of Psychiatry and Behavioral Sciences, McGovern Medical School, UTHealth Houston, Houston, Texas, USA., Nunes PV; Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil., Olagunju AT; Department of Psychiatry and Behavioral Neurosciences, McMaster University/St Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada., Oluwaniyi S; Lagos Federal Neuropsychiatry Hospital, Lagos, Nigeria., Orhan M; Department of Clinical Psychology, Leiden University, Leiden, The Netherlands., Patrick RE; Division of Geriatric Psychiatry, McLean Hospital, Belmont, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA., Radua J; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERSAM, Instituto de Salud Carlos III, University of Barcelona, Barcelona, Spain., Rajji T; Department of Psychiatry, Toronto Dementia Research Alliance, University of Toronto, Toronto, Ontario, Canada., Sarna K; Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Schouws S; GGZ inGeest, Amsterdam UMC, VU Medical Center, Amsterdam, The Netherlands., Simhandl C; Medical Faculty, Bipolar Center Wiener Neustadt, Sigmund Freud University Vienna, Wien, Austria., Sekhon H; Department of Psychiatry, Jewish General Hospital/Lady Davis Institute, McGill University, Montreal, Quebec, Canada., Soares JC; Department of Psychiatry and Behavioral Sciences, University of Texas/McGovern Medical School, Houston, Texas, USA., Sutherland AN; Department of Psychiatry, University of California, San Diego, California, USA.; Desert-Pacific Mental Illness Research Education and Clinical Center, VA San Diego Healthcare System, San Diego, California, USA., Teixeira AL; Department of Psychiatry and Behavioral Sciences, University of Texas/McGovern Medical School, Houston, Texas, USA.; Faculdade Santa Casa BH, Belo Horizonte, Brazil., Tsai S; Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Vidal-Rubio S; Psychiatry Service, Hospital de la Ribera, Valencia, Spain., Vieta E; Bipolar and Depressive Disorders Unit, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, ISCIII Barcelona, Barcelona, Catalonia, Spain., Yala J; Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Eyler LT; Department of Psychiatry, University of California, San Diego, California, USA.; Desert-Pacific Mental Illness Research Education and Clinical Center, VA San Diego Healthcare System, San Diego, California, USA.
Jazyk: angličtina
Zdroj: International journal of geriatric psychiatry [Int J Geriatr Psychiatry] 2024 Mar; Vol. 39 (3), pp. e6057.
DOI: 10.1002/gps.6057
Abstrakt: Objectives: The Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD) project pools archival datasets on older age bipolar disorder (OABD). An initial Wave 1 (W1; n = 1369) analysis found both manic and depressive symptoms reduced among older patients. To replicate this finding, we gathered an independent Wave 2 (W2; n = 1232, mean ± standard deviation age 47.2 ± 13.5, 65% women, 49% aged over 50) dataset.
Design/methods: Using mixed models with random effects for cohort, we examined associations between BD symptoms, somatic burden and age and the contribution of these to functioning in W2 and the combined W1 + W2 sample (n = 2601).
Results: Compared to W1, the W2 sample was younger (p < 0.001), less educated (p < 0.001), more symptomatic (p < 0.001), lower functioning (p < 0.001) and had fewer somatic conditions (p < 0.001). In the full W2, older individuals had reduced manic symptom severity, but age was not associated with depression severity. Age was not associated with functioning in W2. More severe BD symptoms (mania p ≤ 0.001, depression p ≤ 0.001) were associated with worse functioning. Older age was significantly associated with higher somatic burden in the W2 and the W1 + W2 samples, but this burden was not associated with poorer functioning.
Conclusions: In a large, independent sample, older age was associated with less severe mania and more somatic burden (consistent with previous findings), but there was no association of depression with age (different from previous findings). Similar to previous findings, worse BD symptom severity was associated with worse functioning, emphasizing the need for symptom relief in OABD to promote better functioning.
(© 2024 The Authors. International Journal of Geriatric Psychiatry published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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