Pulsed Photothermal Therapy of Solid Tumors as a Precondition for Immunotherapy.

Autor: Farivar N; Department of Experimental Medicine, University of British Columbia, Vancouver, BC, V5Z 1M9, Canada.; Vancouver Prostate Centre, Vancouver, BC, V6H 3Z6, Canada.; Department of Urologic Sciences, University of British Columbia, Vancouver, BC, V5Z 1M9, Canada., Khazamipour N; Department of Experimental Medicine, University of British Columbia, Vancouver, BC, V5Z 1M9, Canada.; Vancouver Prostate Centre, Vancouver, BC, V6H 3Z6, Canada.; Department of Urologic Sciences, University of British Columbia, Vancouver, BC, V5Z 1M9, Canada., Roberts ME; Vancouver Prostate Centre, Vancouver, BC, V6H 3Z6, Canada.; Department of Urologic Sciences, University of British Columbia, Vancouver, BC, V5Z 1M9, Canada., Nelepcu I; Vancouver Prostate Centre, Vancouver, BC, V6H 3Z6, Canada.; Department of Urologic Sciences, University of British Columbia, Vancouver, BC, V5Z 1M9, Canada., Marzban M; Vancouver Prostate Centre, Vancouver, BC, V6H 3Z6, Canada.; Department of Urologic Sciences, University of British Columbia, Vancouver, BC, V5Z 1M9, Canada., Moeen A; Vancouver Prostate Centre, Vancouver, BC, V6H 3Z6, Canada.; Department of Urologic Sciences, University of British Columbia, Vancouver, BC, V5Z 1M9, Canada., Oo HZ; Vancouver Prostate Centre, Vancouver, BC, V6H 3Z6, Canada.; Department of Urologic Sciences, University of British Columbia, Vancouver, BC, V5Z 1M9, Canada., Nakouzi NA; Vancouver Prostate Centre, Vancouver, BC, V6H 3Z6, Canada.; Department of Urologic Sciences, University of British Columbia, Vancouver, BC, V5Z 1M9, Canada., Dolleris C; Dolleris Scientific Corp., 2327 Collingwood Street, Vancouver, BC, V6R 3L2, Canada., Black PC; Vancouver Prostate Centre, Vancouver, BC, V6H 3Z6, Canada.; Department of Urologic Sciences, University of British Columbia, Vancouver, BC, V5Z 1M9, Canada., Daugaard M; Department of Experimental Medicine, University of British Columbia, Vancouver, BC, V5Z 1M9, Canada.; Vancouver Prostate Centre, Vancouver, BC, V6H 3Z6, Canada.; Department of Urologic Sciences, University of British Columbia, Vancouver, BC, V5Z 1M9, Canada.
Jazyk: angličtina
Zdroj: Small (Weinheim an der Bergstrasse, Germany) [Small] 2024 Aug; Vol. 20 (32), pp. e2309495. Date of Electronic Publication: 2024 Mar 21.
DOI: 10.1002/smll.202309495
Abstrakt: Photothermal therapy (PTT) refers to the use of plasmonic nanoparticles to convert electromagnetic radiation in the near infrared region to heat and kill tumor cells. Continuous wave lasers have been used clinically to induce PTT, but the treatment is associated with heat-induced tissue damage that limits usability. Here, the engineering and validation of a novel long-pulsed laser device able to induce selective and localized mild hyperthermia in tumors while reducing the heat affected zone and unwanted damage to surrounding tissue are reported. Long-pulsed PTT induces acute necrotic cell death in heat affected areas and the release of tumor associated antigens. This antigen release triggers maturation and stimulation of CD80/CD86 in dendritic cells in vivo that primes a cytotoxic T cell response. Accordingly, long-pulsed PTT enhances the therapeutic effects of immune checkpoint inhibition and increases survival of mice with bladder cancer. Combined, the data promote long-pulsed PTT as a safe and effective strategy for enhancing therapeutic responses to immune checkpoint inhibitors while minimizing unwanted tissue damage.
(© 2024 The Authors. Small published by Wiley‐VCH GmbH.)
Databáze: MEDLINE
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