Acquired Hemophilia: A Rare Complication of Pediatric Idiopathic Multicentric Castleman Disease.

Autor:	Appell LE; Department of Pediatrics, Division of Pediatric Hematology/Oncology.; Arkansas Children's Hospital, Little Rock Arkansas., Mack JM; Department of Pediatrics, Division of Pediatric Hematology/Oncology.; Arkansas Children's Hospital, Little Rock Arkansas., Farrar JE; Department of Pediatrics, Division of Pediatric Hematology/Oncology.; Arkansas Children's Hospital, Little Rock Arkansas., Roper SN; College of Medicine.; Department of Medicine & Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee., Savage MR; College of Medicine.; Department of Family Medicine, Baptist Health-University of Arkansas for Medical Sciences, Little Rock, Arkansas., Pandey S; Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas., Crary SE; Department of Pediatrics, Division of Pediatric Hematology/Oncology.; Arkansas Children's Hospital, Little Rock Arkansas.
Jazyk:	angličtina
Zdroj:	Pediatrics [Pediatrics] 2024 Apr 01; Vol. 153 (4).
DOI:	10.1542/peds.2023-063168
Abstrakt:	Acquired hemophilia is caused by acquired autoantibodies to 1 of the factors of the coagulation cascade, usually factor VIII or IX, and is an exceedingly rare phenomenon in children. The finding of an acquired factor VIII inhibitor in a pediatric patient with idiopathic multicentric Castleman disease has never been reported. Patients with acquired hemophilia can have life-threatening bleeds that are refractory to blood product support, requiring bypassing agents to manage bleeding symptoms. We present the novel finding of acquired hemophilia resulting from an autoantibody to factor VIII in a pediatric patient with idiopathic multicentric Castleman disease and discuss the optimal management of bleeding in a patient with acquired hemophilia. (Copyright © 2024 by the American Academy of Pediatrics.)
Databáze:	MEDLINE
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