Burden of disease of respiratory syncytial virus in infants, young children and pregnant women and people.

Autor:	Abrams EM; Centre for Immunization Programs, Public Health Agency of Canada, Ottawa, ON.; University of Manitoba, Department of Pediatrics, Section of Allergy and Clinical Immunology, Winnipeg, MB.; University of British Columbia, Department of Pediatrics, Division of Allergy and Immunology, Vancouver, BC., Doyon-Plourde P; Centre for Immunization Programs, Public Health Agency of Canada, Ottawa, ON., Davis P; Centre for Immunization Programs, Public Health Agency of Canada, Ottawa, ON.; University of Ottawa, School of Epidemiology and Public Health, Ottawa, ON., Brousseau N; Institut national de santé publique du Québec, Québec, QC., Irwin A; Yukon Communicable Disease Control, Health and Social Services, Government of Yukon, Whitehorse, YT., Siu W; Centre for Immunization Programs, Public Health Agency of Canada, Ottawa, ON.; University of Ottawa, School of Epidemiology and Public Health, Ottawa, ON., Killikelly A; Centre for Immunization Programs, Public Health Agency of Canada, Ottawa, ON.
Jazyk:	angličtina
Zdroj:	Canada communicable disease report = Releve des maladies transmissibles au Canada [Can Commun Dis Rep] 2024 Jan 01; Vol. 50 (1-2), pp. 1-15. Date of Electronic Publication: 2024 Jan 01 (Print Publication: 2024).
DOI:	10.14745/ccdr.v50i12a01
Abstrakt:	Background: Passive immunization products for infants and pregnant women and people have sparked interest in understanding Canada's respiratory syncytial virus (RSV) burden. This rapid review examines RSV burden of disease in infants, young children and pregnant women and people. Methods: Electronic databases were searched to identify studies and systematic reviews reporting data on outpatient visits, hospitalizations, intensive care unit admissions, deaths and preterm labour associated with RSV. We also contacted Canadian respiratory virus surveillance experts for additional data. Results: Overall, 17 studies on infants and young children and 10 studies on pregnant women and people were included, in addition to primary surveillance data from one Canadian territory (Yukon). There were higher rates of medical utilization for infants than older children. Hospitalization rates were highest in infants under six months (more than 1% annually), with 5% needing intensive care unit admission, but mortality was low. Severe outcomes often occurred in healthy full-term infants and burden was higher than influenza. Respiratory syncytial virus attack rate was 10%-13% among pregnant women and people. Only one study found a higher hospitalization rate in pregnant women and people compared to non-pregnant women and people. Limited evidence was found on intensive care unit admission, death and preterm birth for pregnant women and people. Conclusion: While risk of severe outcomes is larger in high-risk infants and children, healthcare burden is greatest in healthy term infants. The RSV severity for pregnant women and people appears to be similar to that for non-pregnant women and people. Competing Interests: Competing interests None.
Databáze:	MEDLINE
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