Effects of melatonin against experimentally induced apical periodontitis in rats.

Autor: Kırmızı D; Department of Endodontics, Faculty of Dentistry, Near East University, Nicosia, Mersin, Turkey., Sehirli AÖ; Department of Pharmacology, Faculty of Dentistry, Near East University, Nicosia, Mersin, Turkey., Sayiner S; Department of Biochemistry, Faculty of Veterinary Medicine, Near East University, Nicosia, Mersin, Turkey., Orhan K; Department of Maxillofacial Radiology, Faculty of Dentistry, Ankara University, Ankara, Turkey.; Medical Design Application and Research Center (MEDITAM), Ankara University, Ankara, Turkey., Sebai A; Department of Endodontics, Faculty of Dentistry, Near East University, Nicosia, Mersin, Turkey., Aksoy U; Department of Endodontics, Faculty of Dentistry, Near East University, Nicosia, Mersin, Turkey.
Jazyk: angličtina
Zdroj: Australian endodontic journal : the journal of the Australian Society of Endodontology Inc [Aust Endod J] 2024 Aug; Vol. 50 (2), pp. 218-226. Date of Electronic Publication: 2024 Mar 21.
DOI: 10.1111/aej.12841
Abstrakt: Apical periodontitis is an inflammatory condition resulting from microbial invasion in the root canal system, causing periapical tissue destruction and bone resorption. This study investigated melatonin's effects, known for its antioxidant and anti-inflammatory properties, on experimentally induced apical periodontitis in rats. Three groups of rats were studied: control, apical periodontitis and apical periodontitis with melatonin treatment. Proinflammatory cytokines and enzyme levels in blood serum were measured, and micro-CT analysis assessed bone resorption. Results showed significantly elevated cytokines and enzyme levels in the apical periodontitis group compared to the control. However, in the melatonin-treated group, these levels were significantly reduced (p < 0.01-0.001). Micro-CT analysis indicated decreased periapical resorption cavity volume and surface area with melatonin treatment. This suggests that systemic melatonin administration can mitigate inflammation and reduce bone resorption in experimentally induced apical periodontitis in rats, potentially holding promise for human endodontic disease treatment pending further research.
(© 2024 Australian Society of Endodontology Inc.)
Databáze: MEDLINE
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