The interaction between lncRNAs and transcription factors regulating autophagy in human cancers: A comprehensive and therapeutical survey.

Autor: Jasim SA; Medical Laboratory Techniques Department, Al-Maarif University College, Anbar, Iraq., Almajidi YQ; Department of Pharmacy (Pharmaceutics), Baghdad College of Medical Sciences, Baghdad, Iraq., Al-Rashidi RR; Department of Dentistry, Kut University College, Wasit, Iraq., Hjazi A; Department of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia., Ahmad I; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia., Alawadi AHR; College of Technical Engineering, The Islamic University, Najaf, Iraq.; College of Technical Engineering, The Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq.; College of Technical Engineering, The Islamic University of Babylon, Babylon, Iraq., Alwaily ER; Microbiology Research Group, College of Pharmacy, Al-Ayen University, Thi-Qar, Iraq., Alsaab HO; Pharmaceutics and Pharmaceutical Technology, Taif University, Taif, Saudi Arabia., Haslany A; Medical Technical College, Al-Farahidi University, Baghdad, Iraq., Hameed M; Medical Technical College, Al-Farahidi University, Baghdad, Iraq.
Jazyk: angličtina
Zdroj: Cell biochemistry and function [Cell Biochem Funct] 2024 Mar; Vol. 42 (2), pp. e3971.
DOI: 10.1002/cbf.3971
Abstrakt: Autophagy, as a highly conserved cellular process, participates in cellular homeostasis by degradation and recycling of damaged organelles and proteins. Besides, autophagy has been evidenced to play a dual role through cancer initiation and progression. In the early stage, it may have a tumor-suppressive function through inducing apoptosis and removing damaged cells and organelles. However, late stages promote tumor progression by maintaining stemness features and induction of chemoresistance. Therefore, identifying and targeting molecular mechanisms involved in autophagy is a potential therapeutic strategy for human cancers. Multiple transcription factors (TFs) are involved in the regulation of autophagy by modulating the expression of autophagy-related genes (ATGs). In addition, a wide array of long noncoding RNAs (lncRNAs), a group of regulatory ncRNAs, have been evidenced to regulate the function of these autophagy-related TFs through tumorigenesis. Subsequently, the lncRNAs/TFs/ATGs axis shows great potential as a therapeutic target for human cancers. Therefore, this review aimed to summarize new findings about the role of lncRNAs in regulating autophagy-related TFs with therapeutic perspectives.
(© 2024 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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