The 'middle-aging' brain.

Autor: Dohm-Hansen S; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland; INFANT Research Centre, University College Cork, Cork, Ireland; APC Microbiome Ireland, University College Cork, Cork, Ireland., English JA; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland; INFANT Research Centre, University College Cork, Cork, Ireland., Lavelle A; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland; APC Microbiome Ireland, University College Cork, Cork, Ireland., Fitzsimons CP; Swammerdam Institute for Life Sciences, Brain Plasticity Group, University of Amsterdam, Amsterdam, The Netherlands., Lucassen PJ; Swammerdam Institute for Life Sciences, Brain Plasticity Group, University of Amsterdam, Amsterdam, The Netherlands., Nolan YM; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland; APC Microbiome Ireland, University College Cork, Cork, Ireland. Electronic address: y.nolan@ucc.ie.
Jazyk: angličtina
Zdroj: Trends in neurosciences [Trends Neurosci] 2024 Apr; Vol. 47 (4), pp. 259-272. Date of Electronic Publication: 2024 Mar 19.
DOI: 10.1016/j.tins.2024.02.001
Abstrakt: Middle age has historically been an understudied period of life compared to older age, when cognitive and brain health decline are most pronounced, but the scope for intervention may be limited. However, recent research suggests that middle age could mark a shift in brain aging. We review emerging evidence on multiple levels of analysis indicating that midlife is a period defined by unique central and peripheral processes that shape future cognitive trajectories and brain health. Informed by recent developments in aging research and lifespan studies in humans and animal models, we highlight the utility of modeling non-linear changes in study samples with wide subject age ranges to distinguish life stage-specific processes from those acting linearly throughout the lifespan.
Competing Interests: Declaration of interests The authors declare no competing interests in relation to this work.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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