[Translated article] Comparative study of deep lipomas and atypical lipomatous tumours: Malignancy risk factors.

Autor: Merino-Rueda LR; Servicio de Cirugía Ortopédica y Traumatología, Hospital Universitario 12 de Octubre, Madrid, Spain; Servicio de Cirugía Ortopédica y Traumatología, Hospital Universitario La Paz, Madrid, Spain. Electronic address: rodrigomerinorueda@gmaiol.com., Casas-Ramos P; Servicio de Cirugía Ortopédica y Traumatología, Hospital Universitario de León, León, Spain., Honrado-Franco E; Servicio de Anatomía Patológica, Hospital Universitario de León, León, Spain., Izquierdo-García FM; Servicio de Anatomía Patológica, Hospital Universitario de León, León, Spain., Ramos-Pascua LR; Servicio de Cirugía Ortopédica y Traumatología, Hospital Universitario 12 de Octubre, Madrid, Spain.
Jazyk: English; Spanish; Castilian
Zdroj: Revista espanola de cirugia ortopedica y traumatologia [Rev Esp Cir Ortop Traumatol] 2024 Jul-Aug; Vol. 68 (4), pp. T383-T389. Date of Electronic Publication: 2024 Mar 19.
DOI: 10.1016/j.recot.2024.03.005
Abstrakt: Background and Objectives: The diagnostic suspicion of an atypical lipomatous tumour (ALT) is difficult. The aim of this study is to delve into the most controversial diagnostic aspects of the subject.
Material and Method: Observational, longitudinal and retrospective study of a series of 96 deep adipose tumours (75 lipomas and 21 TLA) from 2006 to 2016: demographic, clinical, imaging and pathological variables were analysed and compared, as well as other variables related to treatment and oncological outcomes of the patients. A descriptive analysis of the collected variables was performed for the statistical study. To evaluate the potential predictor variables of malignancy, a multivariate logistic regression analysis was performed, including those that were statistically significant in the univariate analysis.
Results: Older age at diagnosis, lower limb location and larger size were significantly more frequent in ALTs. MRI findings showed no statistically significant differences between the two groups. In multivariate analysis, the same clinical variables were confirmed as predictors of malignancy. In the ROC curve, an optimal cut-off point of 134.0mm was used as a predictor of malignancy.
Conclusions: Advanced age, location in the lower limbs and larger size are risk factors for malignancy in the differential diagnosis of deep lipomas and atypical lipomatous tumours. No radiological variable on MRI reached significance as a predictor of malignancy in our series.
(Copyright © 2024 SECOT. Publicado por Elsevier España, S.L.U. All rights reserved.)
Databáze: MEDLINE
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