The Effect of Clonidine Premedication on Hemodynamic Changes Following Tracheal Intubation and Co 2 Gas Insufflation and Postoperative Shivering In Patients Undergoing Laparoscopic Cholecystectomy; a Randomized Clinical Trial.

Autor:	Entezariasl M; Department of Anesthesiology, School of Medicine, Ardabil University of Medical Sciences, Ardebil, Iran., Isazadehfar K; Determinants of Health Research Center, Department of Community Medicine, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran., Raesi M; School of Medicine, Ardabil University of Medical Sciences, Ardebil, Iran.
Jazyk:	angličtina
Zdroj:	The international tinnitus journal [Int Tinnitus J] 2024 Mar 21; Vol. 27 (2), pp. 174-182. Date of Electronic Publication: 2024 Mar 21.
DOI:	10.5935/0946-5448.20230027
Abstrakt:	Background: Laparoscopic cholecystectomy is a proper treatment for cholecystitis but the Carbon dioxide gas which is used in surgery stimulates the sympathetic system and causes hemodynamic changes and postoperative shivering in patients undergoing operations. This study was conducted to evaluate the effects of clonidine on reducing hemodynamic changes during tracheal intubation and Carbon dioxide gas insufflation and postoperative shivering in patients undergoing laparoscopic cholecystectomy. Material and Methods: This prospective, randomized, triple-blind clinical trial was conducted on 60 patients between the 18-70 years-old age group, who were candidates of laparoscopic cholecystectomy surgery. The patients randomized into two groups (30 patients received 150 μg oral clonidine) and 30 patients received 100 mg oral Vitamin C). Heart rate and mean arterial pressure of patients were recorded before anesthesia, before and after laryngoscopy, before and after Carbon dioxide gas insufflation. Data were analyzed using Chi-2, student t-test, and analysis of variance by repeated measure considering at a significant level less than 0.05. Results: The findings of this study showed that both heart rate and mean arterial pressure in clonidine group after tracheal intubation and Carbon dioxide gas insufflation were lower than patients in the placebo group, but there was not any statistically significant difference between the two groups (p>0.05) and also postoperative shivering was not different in groups. There was no significant statistical difference in postoperative shivering between the two groups (p>0.05). Conclusion: Using 150 μg oral clonidine as a cheap and affordable premedication in patients undergoing laparoscopic cholecystectomy improves hemodynamic stability during operation.
Databáze:	MEDLINE
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