ANCA in patients with systemic lupus erythematosus. A cross sectional study in Brazilian patients and review of literature.

Autor: Nisihara R; Department of Medicine, Mackenzie Evangelical School of Medicine of Paraná, Curitiba, Brazil.; Departament of Clínica Médica, Federal University of Paraná, Curitiba, Brazil., Vithoft G; Department of Medicine, Mackenzie Evangelical School of Medicine of Paraná, Curitiba, Brazil., Alencar I; Department of Medicine, Mackenzie Evangelical School of Medicine of Paraná, Curitiba, Brazil., Dos Santos TAFG; Department of Medicine, Mackenzie Evangelical School of Medicine of Paraná, Curitiba, Brazil., Skare TL; Department of Medicine, Mackenzie Evangelical School of Medicine of Paraná, Curitiba, Brazil.
Jazyk: angličtina
Zdroj: Lupus [Lupus] 2024 May; Vol. 33 (6), pp. 574-586. Date of Electronic Publication: 2024 Mar 20.
DOI: 10.1177/09612033241240588
Abstrakt: Background: Antineutrophil cytoplasmatic antibodies (ANCA) have been detected in patients with systemic lupus erythematosus (SLE). In this study, we investigated the presence of ANCA in a sample of Brazilian SLE patients and its possible associations with clinical and serological outcomes. Additionally, we reviewed the literature of on ANCA in SLE.
Results: The presence of ANCA was detected in 130 patients using indirect immunofluorescence (IIF). The test was positive in 29.9% of the cases (17.6% pANCA and 11.5% cANCA). Male sex and peripheral vasculitis were more prevalent in the ANCA-positive sample. cANCA was associated with lupus anticoagulant and pANCA had a positive association with peripheral vasculitis and a negative association with anti- SSB/La antibodies. In the 22 studies included in the literature review, a wide range of ANCA positivity was found (13% to 81.1% by IIF and 0 to 22.2% by ELISA). ANCA was associated with renal damage in the Asian population. Although other associations have been found in isolated studies, they were not consistently reported.
Conclusions: The ANCA prevalence found in this Brazilian sample was within the range reported in the literature and these autoantibodies were more frequent in males and in patients with vasculitis. The literature showed controversial results on the association between ANCA and SLE disease activity or clinical characteristics.
Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze: MEDLINE
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