Brain banking in the United States and Europe: Importance, challenges, and future trends.

Autor:	Danner B; Biggs Institute, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA., Gonzalez AD; Biggs Institute, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA., Corbett WC; Biggs Institute, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA., Alhneif M; Biggs Institute, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA., Etemadmoghadam S; Biggs Institute, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA., Parker-Garza J; Biggs Institute, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA., Flanagan ME; Biggs Institute, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA.; Department of Pathology, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA.
Jazyk:	angličtina
Zdroj:	Journal of neuropathology and experimental neurology [J Neuropathol Exp Neurol] 2024 Mar 20; Vol. 83 (4), pp. 219-229.
DOI:	10.1093/jnen/nlae014
Abstrakt:	In recent years, brain banks have become valuable resources for examining the molecular underpinnings of various neurological and psychological disorders including Alzheimer disease and Parkinson disease. However, the availability of brain tissue has significantly declined. Proper collection, preparation, and preservation of postmortem autopsy tissue are essential for optimal downstream brain tissue distribution and experimentation. Collaborations between brain banks through larger networks such as NeuroBioBank with centralized sample request mechanisms promote tissue distribution where brain donations are disproportionately lower. Collaborations between brain banking networks also help to standardize the brain donation and sample preparation processes, ensuring proper distribution and experimentation. Ethical brain donation and thorough processing enhances the responsible conduct of scientific studies. Education and outreach programs that foster collaboration between hospitals, nursing homes, neuropathologists, and other research scientists help to alleviate concerns among potential brain donors. Furthermore, ensuring that biorepositories accurately reflect the true demographics of communities will result in research data that reliably represent populations. Implementing these measures will grant scientists improved access to brain tissue, facilitating a deeper understanding of the neurological diseases that impact millions. (© The Author(s) 2024. Published by Oxford University Press on behalf of American Association of Neuropathologists, Inc.)
Databáze:	MEDLINE
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