Relevance of Tumor Budding and Pattern of Invasion in Oral Squamous Cell Carcinoma.

Autor: Deshpande NS; Department of Pathology, Dr. BVP Rural Medical College, Pravara Institute of Medical Sciences (DU), Ahmednagar, Maharashtra, India., Munemane AB; Department of Pathology, Dr. BVP Rural Medical College, Pravara Institute of Medical Sciences (DU), Ahmednagar, Maharashtra, India., Karle RR; Department of Pathology, Dr. BVP Rural Medical College, Pravara Institute of Medical Sciences (DU), Ahmednagar, Maharashtra, India., Dongre SD; Department of Pathology, Dr. BVP Rural Medical College, Pravara Institute of Medical Sciences (DU), Ahmednagar, Maharashtra, India.
Jazyk: angličtina
Zdroj: International journal of applied & basic medical research [Int J Appl Basic Med Res] 2024 Jan-Mar; Vol. 14 (1), pp. 29-34. Date of Electronic Publication: 2024 Feb 20.
DOI: 10.4103/ijabmr.ijabmr_391_23
Abstrakt: Background: Standard histopathological parameters such as depth of invasion (DOI), lymphovascular invasion (LVI), and perineural invasion (PNI) are known parameters that can correlate with the prognosis and aggressiveness of oral squamous cell carcinomas (OSCCs). Tumor budding (TB) (≤5 tumor cells at infiltrating borders) and pattern of invasion (POI) are emerging histopathological parameters that have shown promising results as reliable risk factors in predicting nodal metastasis in early OSCCs.
Aim: The aim of the study was to assess TB and POI in OSCCs.
Materials and Methods: A total of 33 surgical resection specimens of OSCC, including buccal mucosa and tongue with neck dissection, were selected. TB and POI along with standard parameters such as grade, DOI, LVI, PNI, lymph node status, and pathological staging were evaluated. These parameters were analyzed in comparison with lymph node involvement and pathological stage of the tumor using the Chi-square and Fischer's exact test. The SPSS software, v21, was used for statistical analyses.
Results: Most of OSCC were moderately differentiated tumors (63.64%). TB was present in 23 cases, in which 69.57% of cases showed low TB (<5 buds), while 30.43% of cases had higher TB (>5 buds). The worst POI (Patterns 4 and 5) was seen in 75.76% of cases. TB, POI, grade, PNI, DOI, and stromal pattern were significantly associated with the pathological stage of the tumor.
Conclusion: TB and POI are important and reliable in histopathological parameters in OSCCs.
Competing Interests: There are no conflicts of interest.
(Copyright: © 2024 International Journal of Applied and Basic Medical Research.)
Databáze: MEDLINE
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