Lifestyle intervention in children with obesity and nonalcoholic fatty liver disease (NAFLD): study protocol for a randomized controlled trial in Ningbo city (the SCIENT study).

Autor: Zhang PP; Ningbo Center for Healthy Lifestyle Research, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang Province, 315000, China., Wang YX; Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, 100191, China., Shen FJ; Department of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang Province, 315000, China., Xing YF; Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, 100191, China., Gu JY; Ningbo Center for Healthy Lifestyle Research, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang Province, 315000, China., Li XY; Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, 100191, China., Jin H; Department of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang Province, 315000, China., Jin SF; Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, 100191, China., Xu M; Department of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang Province, 315000, China., Wang HJ; Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, 100191, China., Wang H; Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, 100191, China. huiwang@bjmu.edu.cn., Li L; Department of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang Province, 315000, China. lilyningbo@163.com.
Jazyk: angličtina
Zdroj: Trials [Trials] 2024 Mar 20; Vol. 25 (1), pp. 196. Date of Electronic Publication: 2024 Mar 20.
DOI: 10.1186/s13063-024-08046-4
Abstrakt: Background: The increasing prevalence of childhood obesity has become an urgent public health problem, evidence showed that intervention for childhood obesity bring enormous health benefits. However, an effective individualized intervention strategy remains to be developed, and the accompanying remission of related complications, such as nonalcoholic fatty liver disease (NAFLD), needs to be assessed. This study aimed to develop an m-Health-assisted lifestyle intervention program targeting overweight/obese children and assess its effectiveness on indicators of adiposity and NAFLD.
Methods: This is a cluster-randomized controlled trial that conducted in children with overweight/obesity in Ningbo city, Zhejiang Province, China. Students in Grade 3 (8-10 years old) were recruited from six primary schools, with three be randomized to intervention group and three to usual practice group. The intervention program will last for one academic year and consists of health education, dietary guidance, and physical activity reinforcement. This program is characterized by encouraging four stakeholders, including School, Clinic, famIly, and studENT (SCIENT), to participate in controlling childhood obesity, assisted by m-Health technology. Assessments will be conducted at baseline and 3 months, 9 months, 24 months, and 36 months after baseline. The primary outcome will be the differences between the two groups in students' body mass index and fatty liver index at the end of the intervention (9 months after baseline). During the implementation process, quality control methods will be adopted.
Discussion: The program will test the effectiveness of the m-Health-assisted lifestyle intervention on children with obesity and NAFLD. The results of this study will provide evidence for establishing effective lifestyle intervention strategy aimed at childhood obesity and NAFLD and may help develop guidelines for the treatment of obesity and NAFLD in Chinese children.
Trial Registration: Clinicaltrials.gov NCT05482191. Registered on July 2022.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje