Novel Image-Guided Percutaneous Lung Tissue Excision Device With Integrated Sealing of Blood Vessels and Airways: An In Vivo Preclinical Study.

Autor:	Salazar JE; Prana Thoracic, Houston, TX, USA., Fischel R; Department of Surgery, University of California Irvine, CA, USA., Bueche KM; Prana Thoracic, Houston, TX, USA., Samra K; Prana Thoracic, Houston, TX, USA., Gonzalez L; Prana Thoracic, Houston, TX, USA., Nathan JC; Prana Thoracic, Houston, TX, USA., Lu C; Prana Thoracic, Houston, TX, USA., Rodriguez J; Prana Thoracic, Houston, TX, USA., Nguyen S; Prana Thoracic, Houston, TX, USA., Cohn WE; Department of Surgery, Baylor College of Medicine, Houston, TX, USA., Boyle E; Department of Thoracic Surgery, St. Charles Medical Center, Bend, OR, USA.
Jazyk:	angličtina
Zdroj:	Innovations (Philadelphia, Pa.) [Innovations (Phila)] 2024 Mar-Apr; Vol. 19 (2), pp. 143-149. Date of Electronic Publication: 2024 Mar 19.
DOI:	10.1177/15569845241234647
Abstrakt:	Objective: This study evaluated the efficacy of the Minimally Invasive Targeted Resection (MiTR) device, a novel electrosurgical instrument that allows for targeted excision of a lung abnormality while using bipolar radiofrequency (RF) energy to seal blood vessels and airways. Methods: The MiTR system was evaluated in 7 acute and 2 chronic porcine (7-day) models to evaluate the efficacy of tissue excision with bipolar RF sealing of blood vessels and airways and application of an autologous blood patch into the excised tissue cavity. Air leak was recorded for all evaluations. The study was approved by the institutional ethical board. Results: Nineteen lung tissue samples, measuring 2.5 cm long × 1.2 cm diameter, were excised. In 8 of 9 animals (89%), hemostasis and pneumostasis were observed visually at the completion of the procedure. In 2 of 2 chronic animals (100%), hemostasis and pneumostasis persisted for the 7-day observation period. Histologic examination of the excised samples showed preservation of the core parenchymal architecture without evident tissue damage of the samples that would impair pathologic analysis. Conclusions: Percutaneous resection of targeted lung tissue with the MiTR system demonstrated hemostasis and pneumostasis while obtaining a histologically intact sample. After regulatory approval, the use of this device could offer more tissue for analysis than a transthoracic needle biopsy or bronchoscopy and a far less invasive alternative to video-assisted thoracic surgery or thoracotomy. This may also expand patient and physician options for the early diagnosis and treatment of lung cancer. Competing Interests: Declaration of Conflicting InterestsThe authors declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: The named authors are shareholders in, consultants to, or employees of Prana Thoracic, Inc. Dr. Fischel is chief medical officer of Prana Thoracic, Inc. The authors maintained full control over the study and acknowledge their responsibility for its design, analysis, honesty, and accuracy.
Databáze:	MEDLINE
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