Patterns of reproductive health in inflammatory rheumatic diseases and other immune-mediated diseases: a nationwide registry study.

Autor:	Kerola AM; Department of Rheumatology, Inflammation Center, Helsinki University Hospital, Helsinki, Finland.; Faculty of Medicine, University of Helsinki, Helsinki, Finland., Palomäki A; Centre for Rheumatology and Clinical Immunology, Turku University Hospital, Turku, Finland.; Department of Medicine, University of Turku, Turku, Finland., Laivuori H; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.; Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Department of Obstetrics and Gynaecology, Tampere University Hospital, Tampere, Finland.; Centre for Child, Adolescent, and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Laitinen T; Tampere University Hospital, Pirkanmaa Wellbeing Services County, Tampere, Finland., Färkkilä M; Abdominal Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Eklund KK; Department of Rheumatology, Inflammation Center, Helsinki University Hospital, Helsinki, Finland.; ORTON Orthopaedic Hospital of the Orton Foundation, Helsinki, Finland., Ripatti S; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Massachusetts General Hospital, Boston, MA, USA., Perola M; Finnish Institute for Health and Welfare, Helsinki, Finland., Ganna A; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Massachusetts General Hospital, Boston, MA, USA., Lindbohm JV; Department of Public Health, University of Helsinki, Helsinki, Finland.; The Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Faculty of Brain Sciences, University College London, London, UK., Mars N; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Jazyk:	angličtina
Zdroj:	Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2024 Oct 01; Vol. 63 (10), pp. 2701-2710.
DOI:	10.1093/rheumatology/keae122
Abstrakt:	Objectives: Rheumatic diseases may impair reproductive success and pregnancy outcomes, but systematic evaluations across diseases are lacking. We conducted a nationwide cohort study to examine the impact of rheumatic diseases on reproductive health measures, comparing the impacts with those of other immune-mediated diseases (IMDs). Methods: Out of all of the 5 339 804 Finnish citizens, individuals born 1964-1984 and diagnosed with any of the 19 IMDs before age 30 (women) or 35 (men) were matched with 20 controls by birth year, sex, and education. We used data from nationwide health registers to study the impact of IMDs on reproductive health measures, such as reproductive success and, for women, ever having experienced adverse maternal and perinatal outcomes. Results: Several of the rheumatic diseases, particularly SLE, JIA, and seropositive RA, were associated with higher rates of childlessness and fewer children. The risks for pre-eclampsia, newborns being small for gestational age, preterm delivery, non-elective Caesarean sections, and need of neonatal intensive care were increased in many IMDs. Particularly, SLE, SS, type 1 diabetes, and Addison's disease showed >2-fold risks for some of these outcomes. In most rheumatic diseases, moderate (1.1-1.5-fold) risk increases were observed for diverse adverse pregnancy outcomes, with similar effects in IBD, celiac disease, asthma, ITP, and psoriasis. Conclusion: Rheumatic diseases have a broad impact on reproductive health, with effects comparable with that of several other IMDs. Of the rheumatic diseases, SLE and SS conferred the largest risk increases on perinatal adverse event outcomes. (© The Author(s) 2024. Published by Oxford University Press on behalf of the British Society for Rheumatology.)
Databáze:	MEDLINE
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