Quantitative evaluation of morphological and functional changes in meibomian glands and lipid layer thickness in patients with and without keratoconus.

Autor: Hou X; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, No.7 Jinsui Road, Tianhe District, Guangzhou, 510060, China.; Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China.; Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, 510060, China., Liu C; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, No.7 Jinsui Road, Tianhe District, Guangzhou, 510060, China.; Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China.; Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, 510060, China., Luo Y; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, No.7 Jinsui Road, Tianhe District, Guangzhou, 510060, China.; Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China.; Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, 510060, China., Yu N; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, No.7 Jinsui Road, Tianhe District, Guangzhou, 510060, China.; Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China.; Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, 510060, China., Chen P; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, No.7 Jinsui Road, Tianhe District, Guangzhou, 510060, China.; Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China.; Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, 510060, China., Zhuang J; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, No.7 Jinsui Road, Tianhe District, Guangzhou, 510060, China. zhuangj@mail.sysu.edu.cn.; Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China. zhuangj@mail.sysu.edu.cn.; Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, 510060, China. zhuangj@mail.sysu.edu.cn., Yu K; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, No.7 Jinsui Road, Tianhe District, Guangzhou, 510060, China. yukeming@mail.sysu.edu.cn.; Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China. yukeming@mail.sysu.edu.cn.; Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, 510060, China. yukeming@mail.sysu.edu.cn.
Jazyk: angličtina
Zdroj: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie [Graefes Arch Clin Exp Ophthalmol] 2024 Aug; Vol. 262 (8), pp. 2551-2560. Date of Electronic Publication: 2024 Mar 19.
DOI: 10.1007/s00417-024-06443-8
Abstrakt: Purpose: To quantitatively evaluate the morphological parameters of meibomian glands (MGs) and lipid layer thickness (LLT) in patients with keratoconus (KC).
Methods: In this prospective, cross-sectional study, 164 eyes of 164 keratoconus patients and 64 eyes of 64 age-matched control subjects were included. An advanced automatic MG analyzer was used to quantitatively measure the morphological and functional parameters of MGs. Morphological and functional parameters of MGs, LLT, and other ocular surface parameters were compared between the control and KC groups.
Results: The mean meibomian gland diameter, length, square, and gland area ratio (GA) were all significantly decreased in the KC group (all P < 0.05), while no significant difference was observed in the gland tortuosity index (TI) and gland signal index (SI) between the KC and control groups (all P > 0.05). There was no significant difference in the number of total and incomplete blinking among patients with different stages of keratoconus (all P > 0.05). The gland diameter, square, and TI were all negatively associated with KC severity (all P < 0.05), while no significant difference was observed among all stages of KC in gland length, GA, and SI (all P > 0.05). Moreover, the LLTs were positively correlated with the gland diameter, square, GA, and TI and negatively correlated with anterior corneal curvature or KC severity (all P < 0.05).
Conclusions: Atrophic morphological changes in the meibomian glands were closely correlated with the severity of keratoconus. Gland diameter may be a sensitive functional morphology metric of meibomian glands in patients with keratoconus.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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