Chronic traumatic encephalopathy neuropathologic change in former Australian rugby players.

Autor: Shepherd CE; Neuroscience Research Australia, Randwick, New South Wales, Australia.; School of Biomedical Sciences, University of New South Wales, Kensington, New South Wales, Australia., McCann H; Neuroscience Research Australia, Randwick, New South Wales, Australia., McLean CA; Department of Anatomical Pathology, Alfred Health, Melbourne, Victoria, Australia., Iverson GL; Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, Massachusetts, USA.; Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Charlestown, Massachusetts, USA.; Department of Physical Medicine and Rehabilitation, Schoen Adams Research Institute at Spaulding Rehabilitation, Charlestown, Massachusetts, USA.; Home Base, A Red Sox Foundation and Massachusetts General Hospital Program, Charlestown, Massachusetts, USA.; Mass General for Children Sports Concussion Program, Boston, Massachusetts, USA., Gardner AJ; Sydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia.; School of Medicine and Public Health, College of Health, Medicine and Wellbeing, The University of Newcastle, Callaghan, New South Wales, Australia.; Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia.
Jazyk: angličtina
Zdroj: Neuropathology and applied neurobiology [Neuropathol Appl Neurobiol] 2024 Apr; Vol. 50 (2), pp. e12972.
DOI: 10.1111/nan.12972
Abstrakt: Aims: We applied the 2021 consensus criteria for both chronic traumatic encephalopathy neuropathological change and traumatic encephalopathy syndrome in a small case series of six former elite-level Australian rugby code players.
Methods: Neuropathological assessment of these cases was carried out at the Sydney and Victorian Brain Banks. Clinical data were collected via clinical interviews and health questionnaires completed by the participants and/or their next of kin, and neuropsychological testing was conducted with participants who were capable of completing this testing.
Results: All cases exhibited progressive cognitive impairment during life. Chronic traumatic encephalopathy neuropathological change was identified in four out of the six cases. However, coexisting neuropathologies were common, with limbic-predominant age-related TDP-43 encephalopathy and ageing-related tau astrogliopathy seen in all cases, intermediate or high Alzheimer's disease neuropathological change seen in four cases and hippocampal sclerosis seen in two of the six cases.
Conclusion: The presence of multiple neuropathologies in these cases complicates clinical diagnostic efforts for traumatic encephalopathy syndrome. It will be important for further clinicopathological studies on larger groups to report all neuropathological comorbidities found in cases diagnosed with either chronic traumatic encephalopathy neuropathological change and/or traumatic encephalopathy syndrome.
(© 2024 The Authors. Neuropathology and Applied Neurobiology published by John Wiley & Sons Ltd on behalf of British Neuropathological Society.)
Databáze: MEDLINE
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