No association between long-chain n-3 fatty acid intake during pregnancy and risk of type 1 diabetes in offspring in two large Scandinavian pregnancy cohorts.

Autor: Lund-Blix NA; Norwegian Institute of Public Health, Oslo, Norway., Bjerregaard AA; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.; Centre for Clinical Research and Prevention, Copenhagen University Hospitals - Bispebjerg and Frederiksberg, Frederiksberg, Denmark., Tapia G; Norwegian Institute of Public Health, Oslo, Norway., Størdal K; Norwegian Institute of Public Health, Oslo, Norway.; Faculty of Medicine, Division of Paediatric and Adolescent Medicine, University of Oslo, Oslo, Norway.; Division of Paediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway., Brantsæter AL; Norwegian Institute of Public Health, Oslo, Norway., Strøm M; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.; University of the Faroe Islands, Torshavn, Faroe Islands., Halldorsson TI; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.; Faculty of Food Science and Nutrition, University of Iceland, Reykjavik, Iceland., Granstrøm C; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Svensson J; Steno Diabetes Center Copenhagen, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Joner G; Faculty of Medicine, Division of Paediatric and Adolescent Medicine, University of Oslo, Oslo, Norway.; Division of Paediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway., Skrivarhaug T; Faculty of Medicine, Division of Paediatric and Adolescent Medicine, University of Oslo, Oslo, Norway.; Division of Paediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway., Njølstad PR; Mohn Research Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.; Children and Youth Clinic, Haukeland University Hospital, Bergen, Norway., Olsen SF; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.; University of the Faroe Islands, Torshavn, Faroe Islands.; Department of Public Health, University of Copenhagen, Copenhagen, Denmark.; Harvard TH Chan School of Public Health, Boston, MA, USA., Stene LC; Norwegian Institute of Public Health, Oslo, Norway. lars.christian.stene@fhi.no.
Jazyk: angličtina
Zdroj: Diabetologia [Diabetologia] 2024 Jun; Vol. 67 (6), pp. 1023-1028. Date of Electronic Publication: 2024 Mar 19.
DOI: 10.1007/s00125-024-06125-4
Abstrakt: Aims/hypothesis: The aim of this study was to investigate whether higher dietary intake of marine n-3 fatty acids during pregnancy is associated with a lower risk of type 1 diabetes in children.
Methods: The Danish National Birth Cohort (DNBC) and the Norwegian Mother, Father and Child Cohort Study (MoBa) together include 153,843 mother-child pairs with prospectively collected data on eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) intake during pregnancy from validated food frequency questionnaires. Type 1 diabetes diagnosis in children (n=634) was ascertained from national diabetes registries.
Results: There was no association between the sum of EPA and DHA intake during pregnancy and risk of type 1 diabetes in offspring (pooled HR per g/day of intake: 1.00, 95% CI 0.88, 1.14), with consistent results for both the MoBa and the DNBC. Robustness analyses gave very similar results.
Conclusions/interpretation: Initiation of a trial of EPA and DHA during pregnancy to prevent type 1 diabetes in offspring should not be prioritised.
(© 2024. The Author(s).)
Databáze: MEDLINE
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