Red/NIR-I-Fluorescence Carbon Dots Based on Rhein with Active Oxygen Scavenging and Colitis Targeting for UC Therapeutics.

Autor: Xia J; College of Pharmacy, Chongqing Medical University, Chongqing, 400016, P. R. China., Wang J; Department of Pharmacy, Chongqing Health Center for Women and Children, Women and Children's Hospital of Chongqing Medical University, Chongqing, 401147, P. R. China., Liu F; College of Pharmacy, Chongqing Medical University, Chongqing, 400016, P. R. China., Chen Z; College of Pharmacy, Chongqing Medical University, Chongqing, 400016, P. R. China., Chen C; College of Pharmacy, Chongqing Medical University, Chongqing, 400016, P. R. China., Cheng X; College of Pharmacy, Chongqing Medical University, Chongqing, 400016, P. R. China., Chao Y; College of Pharmacy, Chongqing Medical University, Chongqing, 400016, P. R. China.; Chongqing Pharmacodynamic Evaluation Engineering Technology Research Center, Chongqing, 400016, P. R. China.; Chongqing Key Laboratory for Pharmaceutical Metabolism Research, Chongqing, 400016, P. R. China., Wang Y; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, P. R. China., Deng T; College of Pharmacy, Chongqing Medical University, Chongqing, 400016, P. R. China.; Chongqing Pharmacodynamic Evaluation Engineering Technology Research Center, Chongqing, 400016, P. R. China.; Chongqing Key Laboratory for Pharmaceutical Metabolism Research, Chongqing, 400016, P. R. China.
Jazyk: angličtina
Zdroj: Advanced healthcare materials [Adv Healthc Mater] 2024 Mar 19, pp. e2304674. Date of Electronic Publication: 2024 Mar 19.
DOI: 10.1002/adhm.202304674
Abstrakt: Ulcerative colitis (UC) is a chronic inflammatory disease with uncontrolled inflammation and demage to the intestinal barrier. Rhein, a bioactive compound in traditional Chinese medicine, has anti-inflammatory and intestinal repair effect. However, their clinical application is limited by their hydrophobicity and poor bioavailability. L-arginine, as a complement to NO, has synergistic and attenuating effects. In this paper, red/NIR-I fluorescent carbon dots based on rhein and doped with L-arginine (RA-CDs), which are synthesized by a hydrothermal process without any organic solvents, are reported. RA-CDs preserve a portion of the functional group of the active precursor, increase rhein solubility, and emit red/NIR-I light for biological imaging. In vitro experiments show that RA-CDs scavenge excessive reactive oxygen species (ROS), protect cells from oxidative stress, and enable the fluorescence imaging of inflamed colons. In a DSS-induced UC mouse model, both delayed and prophylactic treatment with RA-CDs via intraperitoneal and tail vein injections alleviate UC severity by reducing intestinal inflammation and restoring the intestinal barrier. This study highlights a novel strategy for treating and imaging UC with poorly soluble small-molecule drugs.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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